期刊文献+

北京市平谷区正常孕妇妊娠早中晚期甲状腺功能变化研究 被引量:19

原文传递
导出
摘要 目的研究北京市平谷区正常孕妇妊娠期甲状腺功能的变化,为准确诊断妊娠不同时期的甲状腺功能状态提供依据,方法 2011年6月至2012年6月期间在首都医科大学平谷教学医院建册并定期孕检的妊娠早、中、晚期孕妇,应用直接化学发光法测定TSH、FT4、TPOAb和TgAb,依据美国生化研究院的标准,选取其中正常人群,其中早期270例、中期377例、晚期218例、计算各期TSH、FT4正常范围。结果北京市平谷区妊娠妇女早、中、晚期TSH、FT4正常范围分别为:TSH:0.05~3.59 mIU/L、0.09~3.70mIU/L、0.15~4.71mIU/L,妊娠早、中期比较差异无统计学意义(P=0.027),中期与晚期、早期与晚期比较差异均有统计学意义(P=0.001);FT4:(12.00~21.52)pmol/L、(11.50~18.41)pmol/L、(8.90~17.74)pmol/L,各期比较,差异均有统计学意义(P=0.001)。结论妊娠期甲状腺功能指标存在明显的波动,各个地区应该建立妊娠期特异性甲状腺功能指标的正常参考范围,对于准确诊断妊娠不同时期的甲状腺功能的状态非常必要。
出处 《中国妇产科临床杂志》 2014年第5期454-455,共2页 Chinese Journal of Clinical Obstetrics and Gynecology
基金 北京市平谷区医院科研项目(pgyy2012-8)
  • 相关文献

参考文献9

二级参考文献45

  • 1Pop VJ, Brouwers EP, Vader HL, et al. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clin Endocrinol ( Oxf), 2003,59:282-288.
  • 2Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during pregnancy and subsequent psychological development in the child. N Engl J Med, 1999,341:549-555.
  • 3Pop VJ, Kuijpens JL, van Baar AL, et al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol (Oxf), 1999, 50 : 149-155.
  • 4Abalovich M, Amino N, Barbour LA, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab, 2007,92:S1- S47.
  • 5李玉姝 单忠艳 滕卫平 等.甲状腺自身抗体TPOAb和TGAb正常值的研究意义[J].中华检验杂志,2006,29:780-783.
  • 6Cuevas E, Auso E, Telefont M, et al. Transient maternal hypothyroxinemia at onset of cortieogenesis alters tangential migration of medial ganglionic eminence-derived neurons. Eur J Neurosci, 2005, 22:541-551.
  • 7Gilbert ME, Sui L, Walker MJ, et al. Thyroid hormone insufficiency during brain development reduces parvalbumin immunoreactivity and inhibitory function in the hippocampus. Endocrinology, 2007,148:92- 102.
  • 8Lavado-Autric R, Auso E, Garcia-Velasco JV, et al. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. J Clin Invest, 2003,111:1073-1082.
  • 9Auso E, Lavado-Autric R, Cuevas E, et al. A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration. Endocrinology, 2004,145 : 4037-4047.
  • 10Rosa MC, Eric J, Beatrice G, et al. Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phases of development . J Clin Endocrinol Metab, 2002,87:1768-1777.

共引文献333

同被引文献161

  • 1滕卫平.论母体甲状腺激素不足对胎儿神经智力发育的影响[J].中华内分泌代谢杂志,2005,21(2):97-98. 被引量:21
  • 2翟丽屏,刘源,秦启亮,刘传蛟,王欣,边建朝,郭晓尉,陈祖培.德州市水源性高碘地区分布与居民食盐现况调查[J].中国地方病防治,2005,20(3):138-140. 被引量:5
  • 3单忠艳,滕卫平.甲状腺疾病与妊娠[J].国际内分泌代谢杂志,2006,26(5):295-302. 被引量:104
  • 4陈功,宋新明,秦蕴石,黄成礼,印童,郑晓瑛.降低出生缺陷危害的行动措施和对策建议[J].中国计划生育学杂志,2007,15(5):284-286. 被引量:7
  • 5乐杰.妇产科学[M].第7版.北京:人民卫生出版社,2007:6
  • 6f.
  • 7Krapels IP,Zielhuis GA,Vroom F,et al.Periconceptional health and lifestyle factors of both parents affect the rish of live-born children with orofacial clefts[J].Birth Defects Res A clin Mol Terato,2009,76(8):613-620.
  • 8Su PY, Huang K, Hao JH, et al. Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant de- velopment: a prospective population - based cohort study in China [ J]. J Clin Endocimol Metab, 2011, 96 (10) : 3234 - 3241.
  • 9Stagnaro - Green A, Abalovich M, Alexander E, et al. Guidelines of the American thyroid association for the diagnosis and manage- ment of thyroid disease during pregnancy and postpartum [ J ]. Thy-roid, 2011, 21(10) : 1081 -1125.
  • 10Dal Lago A, Vaquero E, Pasqualetti P, et al. Prediction of early pregnancy maternal thyroid impairment in women affected with un- explained recurrent misearriage [ J . Hun reprod, 2011, 26 ( 6 ) : 1324 - 1330.

引证文献19

二级引证文献70

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部