摘要
S100A6是EF-手型钙结合蛋白S100家族成员之一,参与炎性反应,调节细胞生长分化、抑制细胞生长、诱导细胞凋亡等.近年来研究发现S100A6对肿瘤的生长、增殖及侵袭有着重要作用,可能会成为肿瘤诊治的新靶点.现对S100A6的分子结构、作用机制及其在消化系统肿瘤中的研究进展等进行综述.
S100A6 is the member of the S100 family of EF-hand calcium-binding proteins,which participates in inflammatory reaction and regulates in cell growth,differentiation,growth inhibition and apoptosis.Recently it has been reported that S100A6 plays a key role in neoplastic transformation,proliferation and invasion of tumor,it may become a potential target in the diagnosis and treatment of tumor.Here is to review the recent advances in the research on this molecule,including its structure,function mechanism,and its relationship with the gastrointestinal cancer and so on.
出处
《肿瘤研究与临床》
CAS
2014年第7期500-503,共4页
Cancer Research and Clinic
