摘要
目的观察中医养阴柔肝化湿解毒方治疗慢性乙型病毒性肝炎的疗效。方法选取2010年9月至2012年9月收治的慢性乙型病毒性肝炎患者64例,随机分为研究组和对照组,各32例。对照组给予澳泰乐颗粒治疗,研究组则采用养阴柔肝化湿解毒方治疗,对比两组患者的临床疗效和不良反应。结果两组患者在治疗后乏力、肝区不适、消化道症状等临床症状和体征均较治疗前明显改善,且研究组改善更明显(χ2=4.95,3.98,P<0.05)。两组患者在治疗后丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBil)、氨基异丁酸(AIb)等肝功能指标与治疗前相比均有显著性差异,且研究组改善更明显(t=3.21,4.22,3.84,5.67,P<0.05)。研究组治疗后乙型肝炎病毒(HBV)DNA、乙型肝炎E抗原(HBeAg)转阴率与对照组相比明显升高,乙型肝炎表面抗体(HBsAb)阳性率则明显下降,差异有统计学意义(χ2=3.89,3.79,6.34,P<0.05)。结论养阴柔肝化湿解毒方治疗慢性乙型病毒性肝炎疗效佳,不良反应少,值得临床推广。
Objective To explore the efficacy of traditional Chinese medicine （TCM） Yangyin Rougan Huashi Jeidu prescription for treating chronic viral hepatitis B. Methods 64 patients with chronic viral hepatitis B from September 2010 to September 2012 were randomly divided into the study group and the eontrol group,32 eases in each group. The eontrol group was given Aotaile Granules treatment,while the study group was treated by Yangyin Rougan Huashi Jeidu prescripton. The clinical efficacy and adverse reactions were compared between two groups. Results The symptoms and signs of hypodynamia,diseomfort of hepatic area and digestive symptoms after treatment in the two groups were significantly improved compared with before treatment,which in the study group were more signicantly improved（χ^2 =4. 95, 3.98, P 〈 0.05）. The liver function indexes of ALT, AST,TBil and ALB after treatment in the two groups were significantly improved compared with before treatment, the difference had statistical significance, which in the study group were more signicantly improved（t= 3.21,4.22,3.84,5.67, P 〈 0.05）.The negative-conversion rates of HBV DNA and HBeAg were increased compared with the control group, while the positive rate of HBsAg was significantly decreased with statistical differences （χ^2=3.98, 3.79, 6.34, P 〈 0.05） . Conclusion The Yangyin Rougan Huashi Jeidu prescription has better effect and less adverse reactions in treating chronic viral hepatitis B,which is worthy of clinical promotion.
出处
《中国药业》
CAS
2014年第18期35-36,共2页
China Pharmaceuticals
