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广州地区不同年龄组支气管哮喘儿童变应原体外检测结果分析 被引量:2

Assays of common allergens in asthmatic children of different age groups in Guangzhou
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摘要 目的观察广州地区不同年龄组支气管哮喘(哮喘)儿童总IgE(TIgE)水平和15种变应原特异性IgE(slgE)的阳性分布情况。方法入选859例小儿呼吸门诊的0~14岁哮喘儿童,采用德国FookeAllergy-O-LIQ变应原检测系统,通过酶联免疫捕获法检测TI姬和变应原sIgE,比较0~2岁、3~5岁、6~10岁和11~14岁组哮喘儿童的TIgE水平和15种变应原slgE的阳性分布差异。结果TIgE在6~10岁组[148.2(260.8)IU/ml]和11~14岁组[156.5(329.4)IU/ml]分别明显高于0~2岁组[38.7(82.2)IU/ml]和3~5岁组[64.2(138.2)IU/ml](均为P〈0.01)。吸入变应原sIgE阳性率前4位是屋尘(51.9%)、屋尘螨(49.7%)、粉尘螨(47.7%)和热带螨(9.3%),其阳性率均随年龄的增加而t增高,4个年龄组比较差异具有统计学意义(r分别为61.987、125.439、152.507和87.997,均P〈0.01)。食物变应原sIgE阳性率前4位是牛奶(37.7%)、全蛋(23.1%)、花生(6.3%)和小麦粉(5.6%),4个年龄组比较差异具有统计学意义(r分别为50.766、22.913、8.275和7.808,均P〈0.05),牛奶和全蛋的阳性率因年龄的增加而降低,而花生和小麦的阳性率分别在6~10岁组和3~5岁组达高峰后下降。结论广州地区哮喘儿童TIgE水平和主要的吸入变应原屋尘、屋尘螨、粉尘螨及热带螨sIgE阳性率总的变化趋势随年龄的增加而增高,而主要的食物变应原牛奶和鸡蛋的sIgE阳性率则随年龄的增加而下降。 Objective To evaluate the serum total IgE (TIgE) levels and the positivity of specific IgE (sIgE) against 15 common allergens in asthmatic children of different age groups in Guangzhou. Methods A total of 859 asthmatic children aged 0 to 14 years from the out-patient clinics of The First Affiliated Hospital of Guangzhou Medical University were recruited . TIgE and sIgE against 15 common allergens were detected using enzyme-linked immunosorbent assay with the Allergy-O-LIQ system. The levels of TIgE and the positivity of sIgE against individual allergen were compared among the 0-2 year, 3-5 year, 6- 10 year and 11-14 year groups. Results The TIgE levels in 6-10 year group [ 148.2 (260.8) IU/ml ] and 11- 14 year group [ 156.5 (329.4) IU/ml] were markedly higher than those in 0-2 year group [38.7 (82.2)IU/ml] and 3-5 year group [64.2 (138.2)IU/ml] (both P〈0.01 ). The top four aeroallergens were consisted of house dust (51.9%), Dermatophagoicles pteronyssinus ( Der. p) (49.7%), Dermatophagoides farinae ( Der. f) (47.7%) and Blomia tropicalis (9.3%), with the positivity increasing with the age (χ^2=61.987, 125.439, 152.507 and 87.997, all P〈0.01 ). The top four food allergens included milk (37.7%), egg (23.1%), peanut (6.3%) and wheat flour (5.6%) (χ^2=50.766, 22.913, 8.275 and 7.808, all P〈0.05), with the positivity of milk and egg significantly reduced with the age. However, the positivity of peanut and wheat flour culminated in the 6-10 year and 3-5 year groups, followed by reduction thereafter. Conclusion There is a trend towards higher TIgE level and the positivity of major aeroallergens, including house dust, Der. P, Der. f and Blomia tropicalis with the age, whilst the positivity of milk and egg allergens reduces with the age in asthmatic children in Guangzhou.
出处 《中华生物医学工程杂志》 CAS 2014年第2期115-119,共5页 Chinese Journal of Biomedical Engineering
基金 广东省科技厅资助项目(20108031600149)
关键词 儿童 哮喘 变应原 Child Asthma Allergens
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参考文献15

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