期刊文献+

苯磺酸左旋氨氯地平对原发性高血压患者血压变异性及踝臂指数的影响 被引量:2

Effect of levamlodipine besylate on blood pressure variability and ankle-brachial index in patients with essential hypertension
下载PDF
导出
摘要 目的探讨苯磺酸左旋氨氯地平对原发性高血压患者血压变异性(blood pressure variability,BPV)和踝臂指数(Ankle-brachial index,ABI)的影响。方法将78例原发性高血压患者随机分为观察组40例和对照组38例;观察组给予苯磺酸左旋氨氯地平2.5 mg/日降压治疗,对照组给予硝苯地平缓释片20 mg/日降压治疗,治疗6个月,比较两组治疗前后BPV和ABI的变化。结果两组患者治疗后24 h SBP、24 h DBP均显著降低(P<0.01),观察组治疗后24 h SBPV、24 h DBPV较治疗前显著降低(P<0.01),而对照组治疗前后24 h SBPV、24 h DBPV比较差异无统计学意义(P>0.05)。治疗后观察组24 h SBP、24 h DBP、24 h SBPV、24 h DBPV均显著低于对照组(P<0.01)。观察组治疗后ABI与治疗前比较差异有统计学意义(P<0.05),而对照组治疗后ABI与治疗前比较虽有所改善,但差异无统计学意义(P>0.05)。观察组治疗后ABI显著高于对照组(P<0.05)。结论苯磺酸左旋氨氯地平可显著降低高血压患者血压变异性和改善大动脉弹性,从而降低靶器官损害和心血管事件。 Objective To investigate the effect of levamlodipine besylate on blood pressure variability (BPV) and ankle- brachial index (ABI) in patients with essential hypertension.Methods 78 cases with essential hypertension were randomly divided into observation group (40 cases) and control group( 38 cases).2.5 mg/d of levamlodipine besylate was given to the observation group for antihypertensive treatment, and 20 mg/d of received nifedipine was given to the control group for antihy- pertensive treatment.After 6 months of treatment,the changes of BPV and ABI before and after treatment were compared in two groups.Results After treatment,the 24h SBP and 24h DBP in both groups significantly reduced( P 〈0. 01) ,especially those of the observation group after treatment obviously decreased compared with those before treatment ( P 〈0.01 ). However, the control group had no significant difference in 24 h SBPV and 24 h DBPV before and after treatment( P 〉0. 05).The 24 h SBP, 24 h DBP,24 h SBPV and 24 h DBPV of the observation group after treatment were significantly lower than those of the control group( P 〈0. 01).There was statistically significant difference in ABI of the observation group before and after treatment ( P 〈0. 05). Although there was some improvement in ABI of the control group after treatment compared to that before treatment, the difference was not statistically significant( P 〉0.05 ) .The ABI of the observation group after treatment was significantly higher than that of the control group ( P 〈 0.05 ). Conclusion Levamlodipine besylate can obviously reduce the blood pressure variability and improve large artery elasticity of hypertension patients, which can reduce target organ damage and cardiovascular events.
出处 《右江医学》 2014年第4期421-423,共3页 Chinese Youjiang Medical Journal
关键词 高血压病 苯磺酸左旋氨氯地平 血压变异性 踝臂指数 hypertension levamlodipine besylate blood pressure variability ankle-brachial index
  • 相关文献

参考文献11

二级参考文献71

  • 1刘力生.中国高血压防治指南2010[J].中国医学前沿杂志(电子版),2011,3(5):42-93. 被引量:1225
  • 2苏定冯.血压波动性在高血压药物治疗中的意义[J].世界临床药物,2005,26(10):586-588. 被引量:14
  • 3邢绣荣,华琦.解读《中国高血压防治指南(2005年修订版)》(三) 24小时动态血压监测的临床应用[J].中国心血管病研究,2006,4(4):245-247. 被引量:21
  • 4Mancia G,Backer GM,Dominiczak A.2007 Guidelines for the Management of Arterial Hypertension:the Task Force for the Management of Arterial Hypertension of the European Society of Cardiology (ESC).J Hypertens,2007,25:1105-1187.
  • 5Cahan A,Ben-Dov IZ,Mekler J.The role of blood pressure variability in misdiagnosed clinic hypertension.Hypertens Res,2011,34:187-192.
  • 6Chobanian AV,Bakris GL,Black HR.The Seventh Report of the Joint National Committee on Prevention,Detection,Evaluation,and Treatment of High Blood Pressure:the JNC 7 Report.JAMA,2003,21,289:2560-2572.
  • 7Tsioufis C,Andrikou I,Thomopoulos C.Comparative prognostic role of nighttime blood pressure and nondipping profile on renal outcomes.Am J Nephrol,2011,33:277-288.
  • 8Milovanovic B,Trifunovic D,Djuric D.Autonomic nervous system adjustment (ANSA) in patients with hypertension treated with enalapril.Acta Physiol Hung,2011,98:71-84.
  • 9Rothwell PM. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet,2010, 375: 938-948.
  • 10Lawes CMM, Vander Hoom S, Rodgers A. For international society of hypertension. Globalburden of blood-pressure-related disease, 2001. lancet, 2008,371:1513-1518.

共引文献4673

同被引文献26

引证文献2

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部