期刊文献+

经典Wnt信号通路对细胞成骨分化的调控作用 被引量:1

Regulative effect of the canonical Wnt pathway on osteogenesis
原文传递
导出
摘要 Wnt信号通路是参与体内多种器官发育和组织新陈代谢的保守性通路,可分为经典和非经典Wnt信号通路.其中,经典Wnt信号通路通过调节下游的成骨相关转录因子调控细胞成骨分化、骨基质形成和矿化,且在细胞分化的不同阶段发挥不同的调控作用.此外,经典Wnt信号通路还调控牙周组织干细胞成骨分化,该作用受外界微环境的影响.加深对经典Wnt信号通路的认识有助于治疗相关的骨疾病. The Wnt signaling pathway,including the canonical and the non-canonical,is a conservative pathway which participates in organ development and tissue metabolism.The canonical Wnt pathway plays an important role in osteogenesis,bone formation and mineralization through the osteogenesis associated transcription factors.The canonical Wnt pathway also regulates osteogenic differentiation of the stem cells in the periodontal tissue and the regulative effect is influenced by the microenvironment.Understanding of the canonical Wnt pathway will contribute to the treatment of some related bone diseases.
作者 邱绮虹 梁敏
出处 《国际生物医学工程杂志》 CAS 2014年第4期242-246,共5页 International Journal of Biomedical Engineering
基金 国家自然科学基金资助项目(81170970)
关键词 经典Wnt信号通路 成骨分化 牙周组织 治疗 The canonical Wnt pathway Osteogenesis Periodontium Treatment
  • 相关文献

参考文献39

  • 1Nusse R, Varmus HE. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome[J]. Cell, 1982, 31(1): 99-109.
  • 2Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipid- modified and can act as stem cell growth factors[J]. Nature, 2003, 423(6938): 448-452.
  • 3Clevers H, Nusse R. Wnt/beta-catenin signaling and disease[J]. Cell, 2012, 149(6): 1192-1205.
  • 4Logan CY, Nusse R. The Wnt signaling pathway in development and disease[J]. Annu Rev Cell Dev Biol, 2004, 20:781-810.
  • 5Hatzis P, van der Flier LG, van Driel MA, et al. Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells[J]. Mol Cell Biol, 2008, 28(8): 2732-2744.
  • 6MacDonald BT, Tamai K, He Xi. Wnt/beta-catenin signaling: components, mechanisms, and diseases[J]. Dev Cell, 2009, 17(1): 9- 26.
  • 7Matsubara T, Kida K, Yamaguehi A, et al. BMP2 regulates Osterix through Msx2 and Runx2 during osteoblast differentiation[J]. J Biol Chem, 2008, 283(43): 29119-29125.
  • 8Bennett CN, Longo KA, Wright WS, et al. Regulation of osteoblasto- genesis and bone mass by Writ lOb[J]. Proc Natl Acad Sci USA, 2005, 102(9): 3324-3329.
  • 9Bhat RA, Stauffer B, Della Pietra A, et al. Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling[J]. J Cell Biochem, 2010, 109(5): 876-884.
  • 10Cawthorn WP, Bree AJ, Yao Yao, et al. Wnt6, Wntl0a and WntlOb inhibit adipogenesis and stimulate osteoblastogenesis through a beta- catenin-dependent mechanism[J]. Bone, 2012, 50(2): 477-489.

同被引文献4

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部