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基质金属蛋白酶-9与脑缺血后血脑屏障破坏和神经血管重塑 被引量：5

Matrix metaUoproteinase-9 and blood-brain barrier damage and neurovascular remodeling after cerebral ischemia
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摘要 基质金属蛋白酶．9在血脑屏障破坏中起着重要作用。脑缺血后，血脑屏障破坏会直接影响神经血管单元修复。对基质金属蛋白酶-9介导的缺血性脑损伤和神经血管重塑进行深入的研究，有望为临床脑缺血的诊治开辟一条新途径。 Matrix metalloproteinase-9 plays an important role in the blood-brain barrier disruption. Blood-brain barrier disruption may directly influence the neurovascular unit repair after cerebral ischemia. An in-depth study of matrix metalloproteinase-9-mediated ischemic brain damage and neurovascular remodeling is expected to open up a new way for the d/agnosis and treatment of cerebral ischemia in clinical practice.
作者 单丽 孟强
机构地区 昆明医科大学 云南省第一人民医院神经内科
出处 《国际脑血管病杂志》 北大核心 2014年第8期629-632,共4页 International Journal of Cerebrovascular Diseases
基金 云南省中青年学术技术带头人后备人才（2012H13028） 云南省卫生厅卫生系统学科带头人（D-201235） 云南省应用基础研究计划项目（2011FB148）
关键词 卒中 脑缺血 基质金属蛋白酶9 血脑屏障 新生血管化 生理性 神经发生 神经保护药 Stroke Brain Ischemia Matrix Metalloproteinase 9 Blood-Brain Barrier Neovascularization, Physiologic Neurogenesis Neuroprotective Agents
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献39

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同被引文献92

  • 1邓振全,袁建新.进展性脑梗死血清基质金属蛋白酶-9的动态变化及其与病情严重程度及梗死体积的相关性[J].中国老年学杂志,2014,34(3):587-589. 被引量：9
  • 2任韵清,杨森,张学军.米诺环素应用新进展[J].中华皮肤科杂志,2005,38(12):777-778. 被引量：28
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  • 7Zhang ZG, Zhang L,Jiang Q, et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain[J].J Clin Invest, 2000, 106: 829-838.
  • 8LiuJ, Wang Y, Akamatsu Y, et al. Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials[J]. Prog Neurobiol,2014, 115: 138-156.
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国际脑血管病杂志
2014年 第8期

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