摘要
[目的]评价18F-FLT和18F-FDG PET显像在早期评价肺大细胞癌放疗疗效中的作用。[方法]18只荷肺大细胞癌小鼠随机分为18F-FLT和18F-FDG两组,各组又随机配对分为A组、B组、C组,每组3只。A组为对照组,未进行任何治疗;B组于实验前1d对小鼠肿瘤部位进行放疗,单次剂量X线2000cGy,能量6MV;C组于实验前2d同样对小鼠肿瘤部位进行放疗,放疗剂量同B组。经小鼠尾静脉注入18F-FLT和18F-FDG后行MicroPET显像,于注射后60min进行PET显像。[结果]放疗后肺大细胞癌18F-FLT摄取较对照组明显降低(1.33%±0.27%和0.58%±0.08%,P<0.05),FDG组FDG摄取放疗后48h与对照组比较有显著性差异(P<0.05)。PET显像FLT组在放疗后24h、48h后T/NT值明显低于对照组(P<0.05),而FDG放疗组48h与对照组相比有统计学差异(P<0.05)。[结论]18F-FLT可被肺部恶性肿瘤摄取,其特异度高于18F-FDG。放疗引起的18F-FLT摄取变化较18F-FDG灵敏,放疗后18F-FLT摄取降低较18F-FDG明显,因而18F-FLT是一种监测恶性肿瘤放疗疗效的有效的示踪剂。
[Purpose] To investigate the role of18F-fluorothymidine（18F-FLT） and18F-fluorodeoxyglucose（18F-FDG） position emission tomography（PET） imaging for evaluating the efficacy of radiotherapy for large-cell lung carcinoma. [Methods] Eighteen mice bearing lung large cell carcinoma were randomly divided into two groups according to the different tracers（18F-FLT and18F-FDG）,each group was further randomly divided into three sub-groups,group A was control group,group B was treated with 6MV X-ray irradiation of 2000 cGy one fraction in the first day and group C in the second day before the experiment. All mice were injected with18F-FLT or18F-FDG by tail vein. At 60 min after tracers injection,biodistribution and PET imaging were performed. [Results]18F-FLT uptake in murine model of lung large cell carcinoma after irradiation was significantly lower than that of control group（1.33%±0.27%,0.58%±0.08%,P0.05）;18F-FDG uptake after irradiation 48 h was significantly lower than that of control group. PET imaging after radiotherapy 24 h and 48 h,the T/NT value in FLT group was significantly lower than that in control group（P0.05）, while the T/NT value in FLT group was significantly lower than that in control group after 48h（P0.05）.[Conclusion] The uptake of18F-FLT in pulmonary malignant tissues is higher than that in normal tissues,thus the pulmonary neoplasm can be identified accurately with PET imaging. The decrease in tumor18F-FLT uptake after radiotherapy was more pronounced than that of18F-FDG. Therefore,18F-FLT is a promising PET tracer for monitoring response to radiotherapy in oncology.
出处
《中国肿瘤》
CAS
2014年第9期779-784,共6页
China Cancer
基金
北京科学技术委员会首都临床特色应用研究(Z1311070022130231)
