摘要
目的观察匹维溴胺联用小剂量抗抑郁剂度洛西汀对肠易激综合征的临床疗效。方法将138例肠易激综合征患者采用随机双盲法均分为试验组和对照组,试验组给予匹维溴胺联合度洛西汀治疗,对照组给予匹维溴胺治疗,均连续用药8周。分别于治疗1,2,4,8周末对患者进行临床疗效评价,并记录患者症状改善情况及不良反应发生情况。结果治疗第1周末,2组间临床疗效比较差异无统计学意义(P>0.05)。第2,4,8周末两组临床疗效比较,差异有统计学意义(P<0.05);尤其在第8周末差异更为明显,试验组临床总有效率为91.30%,对照组为73.91%。治疗后两组患者抑郁状态均有所改善,但是试验组患者改善更明显(P<0.05)。两组患者均有不良反应发生,但发生率差异无统计学意义(P>0.05)。结论匹维溴胺联用小剂量度洛西汀治疗肠易激综合征,可有效缓解胃肠道症状,且起效快、作用持久,疗效优于单纯口服匹维溴胺,值得临床推广与使用。
Objective To investigate the clinical effects of pinaverium bromide combined with low-dose dutoxetine in treating irritable bowel syndrome （ IBS ） in order to provide the important reference for clinic. Methods 138 patients with IBS were randomly divided into 2 groups. The experimental group was treated with pinaverium bromide combined with dutoxetine, while the control group was treated with simple pinaverium bromide for consecutive 8 weeks. The clinical efficacy was evaluated at the ends of 1, 2, 4, 8 weeks of treatment respectively. The symptoms improvement situation and the occurrence of adverse reactions were recorded. Resuts The clinical efficacy after 1-week treatment had no statistical difference between the two groups （ P〉0. 05 ） , while which at the ends of 2, 4, 8 weeks the difference between the two groups （ P〈0. 05 ）;especially the difference at the end of 8 weeks was more significant. The clinical total ef-fective rate was 91. 3% in the experimental group and 73. 9% in the control group. The depression symptom after treatment in the two groups were improved to some extent, but the improvement in the experimental group was more significant, the difference had statistical significance （ P〈0. 05 ） . The adverse reactions occurred in the two groups without statistical difference （ P〉0. 05 ） . Conclusion Pinaveri-um bromide combined with low-dose dutoxetine in treating IBS can effectively relieve the gastrointestinal symptoms, has rapid effect onset, lasting effect and better therapeutic effect than simple pinaverium bromide, which is worthy of being promoted and applied in clinic.
出处
《中国药业》
CAS
2014年第17期93-95,共3页
China Pharmaceuticals
关键词
肠易激综合征
匹维溴胺
度洛西汀
疗效
irritable bowel syndrome
pinaverium bromide
dutoxetine
effect comparative research
