摘要
目的通过检测慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary diseases,AECOPD)和稳定期患者诱导痰中前列腺素E2(Prostaglandin E2,PGE2)的水平,探讨PGE2在COPD发病机制中的作用。方法选择AECOPD患者52例、稳定期患者48例、健康对照组55例。测定诱导痰上清液中PGE2水平,并分析PGE2浓度气流阻塞之间的相关性。结果 AECOPD患者血清及诱导痰中PGE2水平明显高于COPD缓解期,差异有统计学意义(F=2.268,P<0.05),稳定期COPD组和AECOPD组痰中PGE2水平高于健康对照组,差异有统计学意义(F=2.098,P<0.05;F=2.394,P<0.05)。COPD组患者诱导痰中PGE2浓度与FEV1pred%成负相关(r=-0.58,P<0.05),与FEV1/FVC成负相关(r=-0.74,P<0.05)。结论 PGE2可能参与了COPD的炎症过程,诱导痰中PGE2水平可以作为评价COPD严重程度的指标。
Objective To investigate concentrations of PGE 2 in induced sputum from patients with chronic obstructive pulmonarydisease,and to investigate its clinical significance. Methods The levels of PGE 2 in induced sputum were determined both in 52 case of AECOPD and in 48 cases of stable COPD patients. And we analyzed its correlations with FEV l% pred and FEV 1/FVC %. Results The levels of PGE 2 in the sputum of acute exacerbation and remission stages of COPD groups were both higher than those in the normal control group（F=2. 394,P〈0. 05,F=2. 098,P〈0. 05）. The levels of PGE2 in the acute exacerbation stage were higher than those in the remission stage（F=2. 268,P〈0. 05）. In the COPD group,the levels of PGE2in induced sputum negatively correlated with FEV1% pred（r= -0. 58,P〈0. 05）and FEV1/FVC（r= -0. 74, P〈0. 05）. Conclusion There are different levels of PGE 2 in induced sputum in different periods of COPD,and there are certain relationships between these indexes and pulmonary function. These findings suggest that PGE 2 may participate in the development of COPD and plays an important role in the airway inflammation and airway obstruction of COPD.
出处
《四川医学》
CAS
2014年第9期1189-1191,共3页
Sichuan Medical Journal
