摘要
目的：探讨促红细胞生成素（EPO）对新生儿缺氧缺血性脑病的治疗作用。方法：将2010年1月-2013年10月汕头市妇幼保健院收治的符合中度新生儿缺氧缺血性脑病患儿100例随机分为EPO治疗组和对照组各50例,对照组常规治疗,治疗组在常规治疗基础上加用肌注EPO 200 U·kg-1·d-1,每周3次,根据病情需要连用两周。所有患儿在纠正胎龄40周时进行新生儿神经行为评分（NBNA）,3、6个月时分别进行智能发育测试（CDCC）。结果：EPO治疗组NBNA评分明显高于对照组,差异有统计学意义（P〈0.05）,生后3、6个月智能发育指数明显高于对照组。结论：EPO可明显减少新生儿缺氧缺血性脑病的智力发育异常的发生率。
Objective： To explore the therapeutic effect of erythropoietin （EPO） on neonatal hypoxic - ischemic encephalopathy （HIE） . Methods： One hundred neonates with moderate HIE treated in the hospital from January 2010 to October 2013 were randomly divided into EPO treatment group and control group, 50 neonates in each group; the neonates in control group were treated with conventional therapy, while the neonates in EPO treatment group were treated with intramuscular injection of EPO （200 U · kg^-1 · d^-1 , three times a week） for continuous two weeks based on conventional therapy. Neonatal behavioral neurological assessment （NBNA） was performed among all the neonates with corrected age of 40 weeks in the two groups, CDCC was performed at 3 and 6 months after birth. Results ： NBNA score in EPO treatment group was statistically significantly higher than that in control group （ P 〈 0. 05 ）, mental development indexes at 3 and 6 months after birth in EPO treatment group were significantly higher than those in control group. ConcLusion： EPO can significantly reduce the incidence rate of abnormal intellectual development in neonates with HIE.
出处
《中国妇幼保健》
CAS
北大核心
2014年第26期4264-4265,共2页
Maternal and Child Health Care of China
基金
广东省汕头市科技局重点科技计划项目〔2004(102号)〕
关键词
新生儿
红细胞
神经行为
智能发育
Neonate
Red blood cell
Neurobehavior
Intellectual development
