不同剂量芬太尼对小儿七氟醚麻醉苏醒期躁动的影响被引量：4

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摘要目的：观察不同剂量芬太尼对小儿七氟醚麻醉苏醒期躁动的影响。方法：选择拟于七氟醚麻醉下行扁桃体切除术的患儿60例,年龄3~8岁,随机分为3组。F1组：气管插管前静脉给予1μg/kg的芬太尼,术中每隔30 min追加0.25μg/kg的芬太尼;F2组：气管插管前静脉给予2μg/kg的芬太尼,术中每隔30 min追加0.5μg/kg的芬太尼;C组：对照组,在上述相应时间点给予等量的生理盐水。术中七氟醚维持麻醉。记录各组手术时间、术毕自主呼吸恢复时间、拔管时间（术毕到拔管）和拔管时（T1）、拔管后5 min（T2）、10 min（T3）的躁动发生率以及小儿麻醉后躁动评分（PAED）。结果：F2组术毕自主呼吸恢复时间和拔管时间明显长于对照组与F1组（P〈0.05）;F1和F2组在各个时间点的躁动发生率及PAED评分均明显低于对照组（P〈0.05）。结论：诱导时静注1μg/kg且于术中每隔30 min追加0.25μg/kg的芬太尼可明显降低小儿七氟醚麻醉后躁动的发生率及程度,且不明显增加拔管时间,有利于七氟醚麻醉后的平稳恢复。

作者朱少飞蔡仁贤

机构地区海南省海口市人民医院

出处《中国妇幼保健》 CAS 北大核心 2014年第26期4347-4348,共2页 Maternal and Child Health Care of China

基金海南省卫生厅科研项目〔琼卫2013自筹-43〕

关键词芬太尼小儿七氟醚躁动

分类号 R971.2 [医药卫生—药品]

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1LI Jun HUANG Zhi-lian ZHANG Xu-tong LUO Ke ZHANG Zhan-qin MAO Yi ZHUANG Xiao-biao LIAN Qing-quan CAO Hong.Sufentanil reduces emergence agitation in children receiving sevoflurane anesthesia for adenotonsillectomy compared with fentanyl[J].Chinese Medical Journal,2011(22):3682-3685. 被引量：27

二级参考文献23

1Beskow A,Westrin P.Sevoflurane causes more postoperative agitation in children than does halothane.Acta Anesthesiol Scand 1999; 43:536-541.
2Cohen IT,Finkel JC,Hannallah RS,Hummer KA,Patel KM.The effect of fentanyl on the emergence characteristics after desflurane or sevoflurane anesthesia in children.Anesth Analg 2002; 94:1178-1181.
3Cravero JP.Beach M,Thyr B,Whalen K.The effect of small dose fentanyl on the emergence charactersfics of pediatric patients after sevoflurane anesthesia without surgery.Anesth Analg 2003; 97:364-367.
4Stroumpos C,Manolaraki M,Paspatis GA.Remifentanil,a different opioid:potential clinical applications and safety aspects.Expert Opin Drug Saf 2010; 9:355-364.
5Soulard A,Babre F,Bordes M,Meymat Y,Sztark F,Cros AM.Optimal dose of sufentanil in children for intubation after sevoflurane induction without neuromuscular block.Br J Anaesth 2009; 102:680-685.
6Viby-Mogensen J,Engbaek J,Eriksson LI,Gramstad L,Jensen E,Jensen FS,et al.Good clinical research practice (GCRP) in pharmacodynamic studies of neuromuscular blocking agents.Acta Anesthesiol Scand 1996; 40:59-74.
7Aono J,Ueda W,Mamiya K,Takimoto E,Manabe M.Greater incidence of delirium during recovery from sevoflurane anesthesia in preschool boys.Anesthesiology 1997; 87:1298-1300.
8Sikich N,Lerman J.Development and psychometric evaluation of the pediatric anesthesia emergence delirium scale.Anesthesiology 2004; 100:1138-1145.
9Aldrete JA.The postanesthesia recovery score revisited.J Clin Anesth 1995; 7:89-91.
10Büttner W,Finke W.Analysis of behavioural and physiological parameters for the assessment of postoperative analgesic demand in newborns,infants and young children:a comprehensive report on seven consecutive studies.Paediatr Anaesth 2000; 10:303-318.