摘要
目的探讨血清乳腺癌相关抗原(CA15-3)、血清抗酒石酸盐酸性磷酸酶5b(tartrate-resistant acid phosphatase 5b,TRACP5b)与乳腺癌骨转移程度的相关性。方法选择2012年3月-2013年6月在我院经病理确诊为乳腺癌并经全身骨显像结合临床表现及其他影像学方法确诊的乳腺癌骨转移患者100例及乳腺癌无骨转移患者40例。另选30例经病理证实为乳腺良性病变的患者作为对照组,对上述各组患者进行血清CA15-3、TRACP5b的测定。结果骨转移组血清CA15-3、TRACP5b的水平均明显高于无转移组及良性病变组(P<0.01)。无转移组与良性病变组比较,两项指标均显著增高(P<0.01);骨转移分级越高,血清CA15-3、TRACP5b水平越高(P<0.05),二者与乳腺癌骨转移程度呈显著正相关(r=0.521、0.519,P均<0.001)。结论乳腺癌患者的骨转移程度与血清CA15-3、TRACP5b、B-AKP水平呈显著正相关,骨转移的程度越严重,血清CA15-3、TRACP5b水平越高。
Objective To evaluate the changes of serum marker of breast cancer patients with osseous metastases and their clinical significance by detecting serum breast cancer antigen （CA15-3） and serum anti tartrate-resistant acid phosphatase 5b （TRACP5b）. Methods The patients who were diagnosed with breast cancer by pathology were chosen with 100 cases with bone metastases and 40 cases without bone metastases which were confirmed by the whole body bone imaging combined with clinical manifestation and other imaging methods at the same time. In addition, 30 cases of patients who were diagnosed with breast benign lesion by pathology were chosen as control group. Results The levels of serum CA15-3, TRACP5b in the group of breast cancer with bone metastases were significantly higher than in group without osseous metastases and breast benign lesion group. The levels of serum CA15-3, TRACP5b in the group without osseous metastases were much higher than in group with breast benign lesion group; The degree of osseous metastases of breast cancer and the levels of serum CA15-3, TRACP5b had significant positive correlation, the correlation coefficient was 0.521, 0.519 （P 〈 0.001）, Conclusion The degree of breast cancer with bone metastases and the levels of serum CA15-3, TRACP5b have significant positive correlation, the more serious the degree of bone metastases is, the higher the level of serum CA15-3, TRACP5b is.
出处
《解放军医学院学报》
CAS
2014年第10期1012-1014,共3页
Academic Journal of Chinese PLA Medical School
关键词
乳腺癌
骨转移
全身骨显像
肿瘤标记物
breast cancer
bone metastases
whole body bone scan
tumor markers
