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重组高效抗肿瘤抗病毒蛋白注射液治疗慢性乙型肝炎受试者后血清中和抗体检测

Detection of neutralizing antibody of recombinant potent anti-tumor and anti-virus protein in chronic hepatitis B patients' serum
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摘要 目的考察受试者接受重组高效抗肿瘤抗病毒蛋白治疗后的中和抗体产生情况。方法采用细胞病变效应法检测抗药抗体阳性血清的中和抗体活性。结果抗药抗体阳性血清的中和抗体活性检出率为0%。结论重组高效抗肿瘤抗病毒蛋白治疗后受试者中和抗体产生率低。 Objective activity of neutralizing To investigate the antibody after the recombinant potent anti-tumor and anti virus protein was injected in chronic hepatitisB patients. Methods Apply the cytopathic effects to detect the activity of the neutralizing antibody in the anti-drug antibody positive samples. Results The detection rate of neutralizing antibody activity was 0% in the anti-drug antibody positive samples. Conc I us i on Few neutralizing antibodies produced after the recombinant potent antitumor and anti-virus protein was administrated in patients.
作者 贾敏 王立清 段瑾 陈曦 盛艾娟 王美霞 吕秋军 徐静 王宝亮 梁屹
机构地区 首都医科大学附属北京佑安医院 北京杰华生物技术有限责任公司
出处 《首都医药》 2014年第18期50-52,共3页 Capital Medicine
基金 十二五"重大新药创制-创新药物研究开发"项目(编号:2011ZX09101-008-05)
关键词 重组高效抗肿瘤抗病毒蛋白注射液 中和抗体 细胞病变效应 免疫原性 Recombinant potent anti-tumorand anti-virus protein neutralizing antibody cytopathic effects immunogenicity
分类号 R978.7 [医药卫生—药品]
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参考文献12

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2014年 第18期

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