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栽培尼泊尔菊三七化学成分的研究 被引量:11

Study on chemical constituents from cultivated Gynura nepalensis
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摘要 采用溶剂提取、萃取粗分离、硅胶和Sephadex LH-20凝胶柱色谱以及制备HPLC等纯化技术,从采自北京郊区的尼泊尔菊三七栽培品中分离得到10个化合物。通过波谱分析并参考文献数据鉴定其结构分别为(3R)-3-羟基-β-紫罗兰酮(1)、(3S,5R,6S,7E)-5,6-环氧-3-羟基-7-大柱香波龙烯-9-酮(2)、(+)-boscialin(3)、3,6-反-3-羟基-α-紫罗兰酮(4)、3,6-顺-3-羟基-α-紫罗兰酮(5)、3,4-顺-3,4-二羟基-β-紫罗兰酮(6)、咖啡酸乙酯(7)、黑麦草内酯(8)、3-甲酰基吲哚(9)和3-羟乙酰基吲哚(10)。所有10个化合物均为首次从尼泊尔菊三七中分离鉴定,且化合物1、2、4-7、9和10为首次从菊三七属植物中分离得到。化合物1-6在结构上均属于具有相同的大柱香波龙烷碳架的C13降-倍半萜类化合物,根据本研究,其是尼泊尔菊三七的主要化学成分类别之一,对其植物分类学研究具有一定的参考价值。 Taking application of some isolation and purification technologies, such as solvent extraction, preliminary solvent isolation, column chromatographies over silica gel and Sephadex LH-20 gel and preparative HPLC, 10 compounds were obtained from Gynura nepalensis cultivated in the suburban area of Beijing. Their structures were identified by spectroscopic methods and comparison with literature as (3R) -3-hydroxy-β-ionone ( 1 ), ( 3S, 5R, 6S, 7E) -5,6-epoxy-3-hydmxy-7-megastigmen-9-one ( 2 ), ( + ) -boscialin (3), 3,6-trans-3-hydmxy-a-ionone (4), 5,6-cis-3-hydroxy-a-ionone ( 5 ), 3,4-cis-5,4-dihydroxy-β-ionone ( 6 ), ethyl caffeate (7), loliolide (8), 1 H-indole-3-carbaldehyde (9), and 3- (hydroxyacetyl) indole ( 10 ), respectively. All compounds were isolated from the title plant for the first time, and with compounds 1,2,4-7,9 and 10 being isolated from Gynura species for the first time. Structurally, the above compounds 1-6 belong to C13 nor-sesquiterpenoids, sharing the same carbon skeleton of megastigmane. Accord- ing to this study, they are one of major kinds of chemical constituents of Gynura nepalensis and have important reference value for the investigation on phytotaxonomy of this species.
出处 《中国中药杂志》 CAS CSCD 北大核心 2014年第19期3777-3781,共5页 China Journal of Chinese Materia Medica
基金 国家"重大新药创制"科技重大专项(2012ZX09301002-002)
关键词 尼泊尔菊三七 菊科 化学成分 大柱香波龙烷型C13降-倍半萜 Gynura nepalensis Compositae chemical constituents C13 nor-sesquiterpenoid of megastigmane
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