摘要
采用介质研磨法制备尼莫地平纳米混悬剂以提高药物溶解度。以粒径、多分散系数(PDI)、ζ电位为指标,采用单因素法优化其处方和工艺。优化后制品的粒径为(261.2±5.7)nm、PDI为0.160±0.022、ζ电位为-32 mV。X射线粉末衍射和差示扫描量热分析结果表明纳米冻干粉中药物仍以晶型状态存在。与原药相比,纳米冻干粉的饱和溶解度提高了近60倍。
The nimodipine nanosuspension was prepared by wet milling technique to improve the solubility of nimodipine. The formulation and preparation process were optimized by single factor test with particle size, polydispersity index （PDI） and ζ potential as indexes. The particle size, PDI and ζ potential of the optimal product were （261.2±5.7） nm, 0.160±0.022 and -32 mV, respectively. The results of X-ray powder diffraction （XRPD） and differential scanning calorimetry （DSC） showed that nimodipine in the lyophilized nanosuspension still existed in crystalline form. Compared with the bulk drug, the solubility of nimodipine in the lyophilized nanosuspension was increased by nearly 60 times.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2014年第10期941-945,共5页
Chinese Journal of Pharmaceuticals
基金
上海市科技支撑计划资助项目(10dz1920400)
