摘要
目的优选水杨酸复合微囊的制备工艺条件。方法以复合微囊载药量、包封率、外观、粒径分布等为制备工艺的优化指标,通过L9(34)正交试验,考察了壳聚糖/明胶最佳用量、药料比、乳化剂用量等因素对微囊形成的影响;测定载药微球在人工肠液中的体外释放行为。结果水杨酸复合微囊的最佳制备条件为:药料比0.34 g∶0.34 g、乳化剂4.4 mL、1%壳聚糖、2%明胶;所得微囊成球性好、粒径分布均匀,载药量和包封率分别为31.56%、85.28%,在人工肠液中有缓释效果。结论所优选工艺可制备具有缓释效果的水杨酸壳聚糖-明胶复合微囊。
OBJECTIVE To optimize the preparation condition for microencapsulation of salicylic acid. METHODS The L_9 （3^4 ） orthogonal test designed by adopting the standard of drug encapsulation efficiency, drug loading , visual form and size distribution was applied to study the effects of the optimum amounts of chitosan/gelatin, ratio of salicylic acid to wall materials, and dosage of emulsifi- ers on the formulation of mierocapsule. The release behaviour of this drug - loaded salicylic acid microeapsules in artificial intestinal juice was also investigated. RESULTS The optimum preparation formulation of microencapsulation of salicylic acid was as follows： chitosan dosage （ 1% ） , gelatin dosage （ 2% ） , dosage of emulsifiers （ 4.4 mL） , weight ratio of drug and loading material （ 0.34 g ： 0.34 g）. These salicylic acid microcapsules, which had slow release effect in artificial intestinal juice, were spherical with uniform particle size distribution. And the drug loading and embedding ratio were 31.56% and 85.28% , respectively. CONCLUSION The optical formulation method presented that it can be used to prepare sustained release salicylic acid chitosan - gelatin microcapsules.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2014年第5期494-496,共3页
West China Journal of Pharmaceutical Sciences
基金
国家自然科学基金资助项目(批准号:21106022)
关键词
水杨酸
微囊
正交试验
Salicylic acid
Microcapsules
Orthogonal test
