摘要
目的观察单唾液酸四己糖神经节苷脂钠对Binswanger病患者认知力及日常生活能力的影响。方法将56例Binswanger病患者随机分为治疗组和对照组各28例，两组患者均予常规治疗，治疗组患者在此基础上给予单唾液酸四己糖神经节苷脂钠静滴，对照组患者给予胞二磷胆碱静滴，14天后采用MMSE量表和ADL量表评价两组患者的认知力及日常生活能力变化情况。结果治疗组患者MMSE量表改善总有效率为75％、ADL量表改善总有效率为67．86％，对照组患者MMSE量表改善总有效率为35．71％、ADL量表改善总有效率为32．14％。结论单唾液酸四己糖神经节苷脂钠治疗Binswanger病能够较好改善患者认知力及日常生活能力。
Objective To observe impact of monosialotetrahexosylganglioside （GM1） sodium on cognition and daily living ability of patients with Binswanger. Methods 56 cases of Binswanger were randomly divided into treatment group and control group with 28 cases in each group, and patients were given traditional treatment. Treatment group was added with GM 1 sodium infusion, while control group was treated with citicoline infusion. After 14 days of treatment, changes in cognition and daily living ability of two groups were evaluated by Mini-mental State Examination （MMSE） scale and Activities of Daily Living （ADL） scale. Results For treatment group, the total effective rate of MMSE scale improvement was 75%, and that of ADL scale improvement was 67.86%. But for control group, the total effec, tive rate of MMSE scale improvement was 35.71%, and that of ADL scale improvement was 32.14%.Therefore, the treatment group was significantly superior to the control group, with statistically significant differences （P 〈 0.05）. Conclusion GMI sodium treatment can better improve cognition and daily living ability of patients with Binswanger.
出处
《国际医药卫生导报》
2014年第19期3001-3003,共3页
International Medicine and Health Guidance News
关键词
单唾液酸四己糖神经节苷脂钠
BINSWANGER病
MMSE
ADL
Monosialotetrahexosylganglioside sodium
Binswanger＇ s disease
Mini-mental state examination
Activities of daily living
