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MCL-1在口腔鳞状细胞癌中的表达及意义 被引量：1

The expression of MCL-1 and its significance in oral squamous cells carcinoma
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摘要 目的:探讨MCL-1在口腔鳞状细胞癌(Oral squamous cells carcinoma,OSCC)组织中的表达情况及意义。方法:采用免疫组织化学和实时荧光定量PCR技术,检测OSCC和口腔正常黏膜组织中MCL-1蛋白及mRNA的表达。结果:MCL-1蛋白在OSCC组织中的阳性表达率为61.9%(52/84),在口腔正常黏膜组织中的阳性表达率为15.0%(3/20),两组有显著性差异(P<0.001);MCL-1 mRNA在OSCC肿瘤组织中的含量高于癌旁正常组织(P<0.05)。结论:MCL-1的高表达在OSCC的发展过程中可能发挥了重要作用。 Objective To explore the expression of MCL-1 and its significance in oral squamous cell carcinoma （OSCC）.Methods The expression of MCL-1 protein was detected using immunohistochemistry,and the MCL-1 mRNA was assayed by real-time fluorescent quantitative PCR.Results 52 of 84 samples （61.9%）in OSCC tissues were found to over-express MCL-1 protein,while 3 of 20 samples （15.0%）in oral normal mucosa tissues were found to over-express MCL-1 protein.Statistical differences （P〈0.001）existed between these two groups.The expression of MCL-1 mRNA in OSCC was higher than in OSCC adjacent normal tissues （P〈0.05）.Conclusion The high expression of MCL-1 in OSCC has played an important role in the development of OSCC.
作者 郑军 邬丽苹 王天霆
机构地区 石河子大学医学院第一附属医院口腔科 新疆哈密红星医院口腔科
出处 《中国美容医学》 CAS 2014年第15期1257-1260,共4页 Chinese Journal of Aesthetic Medicine
基金 石河子大学医学院第一附属医院科研项目(SS2011-088)
关键词 口腔鳞状细胞癌 MCL-1 免疫组织化学 实时荧光定量PCR OSCC MCL-1 Immunohistochenistry real-time fluorescent quantitative PCR
分类号 R783 [医药卫生—口腔医学]
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参考文献11

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二级参考文献13

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中国美容医学
2014年 第15期

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