摘要
随着人类生活方式和饮食结构的改变,高尿酸血症和腹型肥胖的发病率逐年升高,且临床研究发现高尿酸血症与腹型肥胖经常在同一个体上出现,两者密切相关。研究发现高尿酸血症并腹型肥胖已成为常见的代谢性疾病,是心脑血管疾病的危险因子。高尿酸血症并腹型肥胖模型的研究,对于阐释高尿酸血症并腹型肥胖的病理及药理机制十分重要。本文就高尿酸血症并腹型肥胖动物模型研究进展进行综述。
Hyperuricemia is closely associated with abdominal obesity .The prevalence of hyperuricemia combined with abdominal obesity has been increased significantly in recent years , along with the improvement of daily life and the changes in dietary structure .The state of hyperuricemia combined with abdominal obesity is most harmful , and becomes a common and high risk metabolic disease .Animal model with hyperuricemia combined with abdominal obesity is very impor-tant for the research of pathomechanism and treatment of this disease .
出处
《中国实验动物学报》
CAS
CSCD
2014年第4期81-85,共5页
Acta Laboratorium Animalis Scientia Sinica
基金
教育部高等学校博士学科点专项科研基金(NO.20130013120001
20120013130002)
北京中医药大学科研创新团队(2011-CXTD-014)
北京中医药大学自主课题(2013-QNJSZX008)
关键词
高尿酸血症
腹型肥胖
动物模型
Hyperuricemia
Abdominal obesity
Animal models
