摘要
目的探讨胃癌组织中周期素D1蛋白的表达在胃癌发生发展中的意义。方法应用免疫组织化学SP法,检测周期素D1在不同类型胃组织中的表达。结果周期素D1在胃癌、胃黏膜上皮中-重度不典型增生、轻度不典型增生、慢性浅表性胃炎和正常胃黏膜组织中的阳性表达率分别为64.41%、47.06%、32.73%、16.33%和5.08%。有病变的胃组织中的周期素D1蛋白表达均高于正常胃黏膜(P<0.05);胃癌组织周期素D1蛋白表达高于其他类型胃组织(P<0.05)。结论周期素D1过表达可能是胃癌发生过程中的早期分子事件。
Objective To study the relationship of cyclin D1 expression and the development of gastric carcinoma. Methods Cyclin D1 expression was detected in different kinds of gastric mucosa by immunohistochemical SP method. Results The positive expression rate of cyclin D1 was 64.41% in gastric carcinoma, which was significantly higher than 32.73% in moderate to severe atypical hyperplasia,47. 06% in slight atypical hyperplasia,47.06% in chronic superficial gastritis and 5.08% in normal gastric mucosa（P〈0. 05）. The expression rate of cyclin D1 was higher in diseased gastric mucosa than that in normal gastric mucosa（P〈0. 05）. Conclusion The overexpression of cyclin D1 in gastric mucosa may be an early molecular event in gastric carcinogenesis.
出处
《江苏医药》
CAS
北大核心
2014年第17期2048-2049,F0003,共3页
Jiangsu Medical Journal
关键词
胃癌
周期素D1
Gastric carcinoma Cyclin D1
