摘要
蛛网膜下腔出血(SAH)是指某些疾病引起的脑血管破裂,血液流至蛛网膜下腔出现的一组症状,是一种高发病率高死亡率的脑血管疾病。脑血管痉挛(CVS)是指颈内动脉或椎基底动脉系统的斑块使脑血管腔狭窄并使血液出现涡流,当涡流加速时,刺激血管壁致血管痉挛而出现短暂性脑缺血发作,旋涡减速时症状消失,是蛛网膜下腔出血一个潜在的致命性并发症。文献表明,炎症反应和氧化应激在CVS的过程中发挥着至关重要的作用,本文就其在SAH后CVS中的研究进展作一综述,以期为临床干预治疗措施提供理论依据。
Subarachnoid hemorrhage （SAH） represents a serious vascular diseases caused by cerebral vascular rupture, accompanied by a group of symptoms caused by blood flow into the subarachnoid space, with a high incidence and mortality. Cerebral vasospasm （CVS） has been considered the potentially fatal complication of SAH. The atherosclerotic plaque in the carotid artery or vertebral basilar artery narrowed the blood vessels and blood flow vortex appears. The vortex acceleration, stimulate blood vessel wall and caused the vasospasm and in turn induced the transient ischemic attack. Domestic and foreign literatures showed that inflammation and oxidative stress plays a crucial role in the process of cerebral vasospasm. The key of this paper is to review the research advances of inflammation in the cerebral vasospasm after subarachnoid hemorrhage, in order to provide a theoretical guidance to clinical intervention measures.
出处
《创伤与急危重病医学》
2014年第5期283-286,295,共5页
Trauma and Critical Care Medicine
关键词
蛛网膜下腔出血
脑血管痉挛
炎症反应
氧化应激
发病机制
subarachnoid hemorrhage
cerebral vasospasm
inflammatory response
oxidative stress
pathogenic mechanism
