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减低剂量HAA方案治疗60~69岁初发急性髓系白血病疗效观察 被引量:2

The efficacy and safety of the reducing dose HAA regimen as induction chemotherapy in previously untreated elderly patients aged 60-69 years with acute myeloid leukemia
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摘要 近几十年来,随着个体化治疗的推动、新药的研发、靶向治疗方案的建立及骨髓移植的开展,年轻急性髓系白血病(AML)患者明显获益,但老年AML由于具有独特的生物学特征及临床特点,其治疗进展有限.目前中老年AML患者约占2/3,但其化疗后完全缓解(CR)率仅为40%~ 60%,且高达85%的患者在2~3年内出现复发.因此亟待设计一种新的化疗方案以提高老年AML患者的缓解率并延长生存时间.我们回顾性分析2004年至2012年接受减低剂量HAA[高三尖杉酯碱(HHT)、阿糖胞昔(Ara-C)与阿克拉霉素(Acla)]方案的14例60~69岁AML患者的疗效和安全性,现报告如下.
出处 《中华血液学杂志》 CAS CSCD 北大核心 2014年第9期845-847,共3页 Chinese Journal of Hematology
基金 卫生公益性行业科研专项(201202017) 国家自然科学基金(81070418H0812) 浙江省重点创新团队(2011R50015)
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