摘要
目的 探讨偏头痛与MRI脑白质异常信号的相关性. 方法 计算机检索PubMed、Ovid、维普、CNKI等数据库中关于偏头痛与MRI脑白质异常信号相关性的病例对照试验,进行Meta分析. 结果 总体评价：偏头痛患者MRI脑白质异常发生率与对照组比较有增高趋势,其比值为3.3,差异有统计学意义[Z=4.530,P=0.000,失安全系数（Nfs）=191].在对照组排除可能引起脑白质异常的其他合并疾病后,偏头痛患者MRI脑白质异常发生率较对照组高,达4.24倍,差异有统计学意义（Z=4.110,P=0.000,Nfs=124）.中文文献研究中偏头痛患者MRI脑白质异常发生率与对照组比较增高,其比值为4.92,差异有统计学意义（Z=3.370,P=0.001,Nfs=5）.英文文献研究中偏头痛患者MRI脑白质异常发生率与对照组比较增高,其比值为3.07,差异有统计学意义（Z=3.930,P=0.000,Nfs=124）.伴先兆偏头痛患者MRI脑白质异常发生率与对照组比较增高,其比值为3.87,差异有统计学意义（Z=3.380,P=0.001,Nfs=102）.无先兆偏头痛患者MRI脑白质异常发生率与对照组比较增高,其比值为2.50,差异有统计学意义（Z=3.480,P=0.001,Nfs=64）. 结论 偏头痛是脑白质异常的危险因素,有先兆偏头痛较无先兆偏头痛的危险度更高.
Objective To investigate the correlation between migraine and abnormal white matter signal in MR imaging.Methods The controlled trail was performed on the relevant cases selected from the data bases of PubMed,Ovid,VIP,CNKI,and then,meta-analysis was implemented.Results The general evaluation showed that patients with migraine had a high trend of abnormal white matter signal in MR imaging as compared with the normal controls （occurrence rate [OR]=3.3,Z=4.53,P=0.000 and fail-safe number [Nfs]=191）.After excluding other complications those might cause abnormal white matter signal,the OR reached to 4.24 （Z=4.110,P=0.000 amd Nfs=124）.As the same as the evaluation of significant difference in Chinese journals （OR=4.92,Z=3.370,P=0.001 and Nfs=5）,the English journals also revealed this difference was statistically significant （OR=3.07,Z=3.930,P=0.000 and Nfs=124）.The difference was significant if abnormal white matter signal was associated with migraine with aura （OR=3.870,Z=3.38,P=0.001 and Nfs=102） and without attra （OR=2.50,Z=3.482,P=0.001 and Nfs=64）.Conclusion Migraine is a risk factor for white matter abnormalities; patients with migraine with aura are at greater risk than those with migraine without aura.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2014年第9期934-938,共5页
Chinese Journal of Neuromedicine
关键词
偏头痛
脑白质病变
荟萃分析
Migraine
White matter abnormality
Meta-analysis
