摘要
目的:系统评价左旋布比卡因与罗哌卡因在剖宫产术后硬膜外镇痛中的疗效。方法:计算机检索重庆维普中文科技期刊全文数据库、万方数据库、中国期刊全文数据库、中国全文数据库(世纪期刊)、中国生物医学文献数据库(网络版)、CNKI数据库中关于左旋布比卡因与罗哌卡因在剖宫产术后硬膜外镇痛中的疗效的随机对照试验,检索时间从1990年1月至2011年12月,对符合标准的随机对照试验(RCT)进行Meta分析。结果:共纳入8个RCT,结果显示罗哌卡因与左旋布比卡因用于剖宫产术后硬膜外镇痛的镇痛效果无明显差异(P=0.13);罗哌卡因与左旋布比卡因相比,下肢运动阻滞弱且恢复时间短(P<0.001),不良反应少(P=0.001)。结论:现有的循证医学证据表明罗哌卡因与左旋布比卡因用于剖宫产术后硬膜外镇痛,具有相似的镇痛效果,且罗哌卡因具有较短的运动阻滞恢复时间和较少的不良反应。
Objective：To evaluate the epidural analgesia efficacy and safety of levobupivacaine and ropivacaine after cesarean.Methods：We searched six databases.Meta-analysis was used to evaluate the data extracted from 1990 to 2011published papers in China on the epidural analgesia efficacy and safety of levobupivacaine and ropivacaine after cesarean.Results：Eight RCTs met the inclusion criteria.The analysis of all eight RCTs showed there was no difference of postoperative analgesia effect between the levobupivacaine and ropivacaine groups（P=0.13）.Compared with levobupivacaine group,ropivacaine group showed weaker lower limb motion block（P〈0.001）and less complications（P=0.001）.Conclusion：Based on existing evidence,there was similar postoperative analgesia effect by levobupivacaine and ropivacaine,but ropivacaine administration had weaker lower limb motion block and less complications as compared with levobupivacaine.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2014年第5期811-815,共5页
Medical Journal of Wuhan University
