摘要
目的评价经支气管动脉灌注化疗栓塞术（bronchial arterial chemoembolization,BACE）治疗中晚期肺癌患者后的远期疗效。方法回顾性分析经病理确诊、年龄在39∽82岁的原发性肺癌或转移性肺癌患者168例,其中男性106例,女性62例,平均年龄67.6岁,鳞癌101例;腺癌41例;小细胞癌及小细胞伴肺内转移13例;混合性癌4例,转移性肺癌9例,均采用Seldinger技术,一般行右股动脉穿刺插管,运用4FCobra导管行支气管动脉造影后行支气管动脉灌注化疗栓塞,造影后予以敏感化疗药物灌注化疗,予聚乙烯醇颗粒、明胶海绵栓塞,3年内随访患者,根据其主观疗效、生存率及生活质量等情况评价其远期疗效。结果 1随访168例不同病理组织细胞类型、不同病理分期的患者于术后反复复查胸部CT、生活质量及3年生存率等均明显不同,表明支气管动脉灌注化疗栓塞术治疗中晚期肺癌的必要性及可行性。2术后3年期间,随访168例肺癌患者目前135例患者已死亡,33例患者仍存活,部分患者出现疼痛症状。结论支气管动脉灌注化疗栓塞术治疗肺癌根据既往文献及本科室研究观察,近期疗效已较为显著。随着我科室对此类患者的随访,初步考虑BACE治疗肺癌患者可以提高患者生存质量及生存时间。
Objective To evaluate the bronchial arterial chemoembolization （BACE） long-term efficacy in the treatment of patients with advanced lung cancer.Methods A retrospective analysis of pathologically confirmed, aged 39-82 years old with primary lung cancer or metastatic lung cancer patients 168 cases, 106 cases were male, 62 female , mean age 67.6 years old（squamous cell carcinoma, adenocarcinoma, small cell carcinoma and small cell lung metastasis, mixed carcinoma, metastatic lung cancer, 101, 41, 13, 4, 9 respective） are using the Seldinger technique,the right femoral artery catheterization, use 4F Cobra underwent bronchial arteriography bronchial artery chemoembolization, after using angiography, polyvinyl alcohol particles , gelatin sponge embolization, based on subjective response, survival and quality of life , etc. Evaluate its long-term effect.Results First, followed up 168 cases of different types of pathological cells, in patients with different pathological stage after repeated review of chest CT, quality of life and 3-year survival was significantly different, indicating that bronchial arterial chemoembolization treatment of advanced lung cancer necessity and feasibility. Second,after 3 years of follow-up 168 cases of lung cancer patients currently have 135 patients died, 33 patients are still alive , some patients pain.Conclusion Bronchial artery chemoembolization treatment of lung cancer based on previous literature and research in our laboratory observation, short-term effect has been more significant. As my department for folloe-up of these patients, preliminary consideration of BACE treatment of lung cancer patients can improve patient quality of life and survival time.
出处
《中国医药指南》
2014年第28期1-1,5,共2页
Guide of China Medicine
基金
四川省教育厅课题(课题号为:11ZA230)
关键词
肺癌
支气管动脉
化疗栓塞
疗效评估
Lung cancer
Bronchial artery
Chemoembolization
Efficacy assessment
