摘要
目的:探讨拉米夫定联合吡喹酮对血吸虫病小鼠肝功能的影响。方法:选择110只健康小鼠作为研究对象,血吸虫病小鼠造模成功后随机分成对照组与观察组,各55只。对照组的小鼠通过吡喹酮灌胃治疗,观察组的小鼠同时联合拉米夫定灌胃治疗。结果:观察组脾脏系数和肝脏系数低于对照组,差异具有统计学意义(P<0.01)。治疗后,两组TbiL(总胆红素)、AST(谷草转氨酶)、ALT(谷丙转氨酶)水平均一定程度下降,且ALB(白蛋白)有所上升,观察组变化幅度大于对照组,差异具有统计学意义(P<0.01)。结论:拉米夫定联合吡喹酮应用于血吸虫病小鼠的治疗中具有较好的效果,能够改善小鼠脏器的水肿与充血,很大程度上促进小鼠肝功能的恢复。
Objective：To study effects of lamivudine combining with praziquantel effects on liver function in mice infected with Schistosoma japonicum.Methods：Selected 110 healthy mice and establish schistosomiasis mice models which were randomly divided into control group and observation group,with 55 rats in each group.Control group was treated with intragastric administration of praziquantel treatment and observation group was treated with praziquantel combining with lamivudine.Results：The spleen index,liver index in mice of the observation group were significant better than in the control group（P〈0.01）.After treatment,TbiL,AST,ALT levels of both groups were decreased,however ALB increased.Changes in the observation group was more obvious than that in the control group（P〈0.01）.Conclusion：Lamivudine combining with praziquantel shows good effects on schistosomiasis mice,it can improve edema and hyperemia,and can promote the recovery of liver function in mice model.
出处
《海南医学院学报》
CAS
2014年第10期1323-1325,共3页
Journal of Hainan Medical University
基金
济南市卫生局资助基金(jn218728)~~
关键词
血吸虫病
小鼠
吡喹酮
拉米夫定
肝功能
Schistosomiasis
Mice
Praziquantel
Lamivudine
Liver function
