摘要
目的 探讨氟对肾脏细胞凋亡的影响。方法 给wistar大鼠饮用含 5 0mg/L氟化钠的高氟水 ,6个月后 ,用TUNEL法和流式细胞术检测大鼠肾脏细胞凋亡。结果 氟能诱导大鼠肾脏TUNEL阳性细胞 ,而且凋亡细胞率较对照组明显增高。结论 研究提示氟可诱导大鼠肾脏细胞凋亡。
Objective To study effects of fluride on apoptosis of kidney cells of rats.Methods Wistar rats were provided with distilled water containing NaF(50mg/L) for six months.Kidney cell apoptosis were detected by TUNEL(TdT mediated dUTP Nick End Labelling)and flow cytometry.Results TUNEL positive cells could be detected in fluoride treated rat kidney,the apoptotic rates of fluoride treated kidney cells were higher than those of the control significantly.Conclusions This result indicated that fluoride could induce kidney cells apoptosis of rats.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2002年第8期897-898,共2页
Chinese Journal of Public Health
基金
"九五"国家医学科技攻关项目 (No.96 - 90 6 - 0 4 - 0 2 )
