摘要
目的 为探讨铝对家兔肝肾的影响。方法 将兔给予不同剂量的硫酸铝钾 8周 ,测定肝、肾组织中铝、铜、锌、锰的含量及SOD、GSH -Px活力 ,同时做病理检查。结果 随着硫酸铝钾摄入量的增加 ,肝肾组织中铝水平升高 (P<0 0 0 1) ,而铜、锌、锰水平有不同程度的下降 (P <0 0 5 ,P <0 0 1) ,SOD活力在高剂量组有显著性降低 (P <0 0 5 ,P<0 0 1) ,而GSH -Px的活力在低、高剂量组均有显著性下降 (P <0 0 5 ,P <0 0 1)。对组织切片光镜下观察 ,低、高剂量组的肝、肾组织均有损伤 ,特别是高剂量组损伤严重。结论 铝通过拮抗其它微量元素而抑制SOD、GSH -Px的活性是造成肝、肾损伤的机理之一。
Objective To investigate the effects of different aluminum (Al) levels on liver and kidney of rabbits.Methods Belgium rabbits were administered with aluminum potassium sulfate successively for eight weeks,and the contents of trace elements Copper (Cu),Zinc (Zn),Manganese (Mn) were analyzed.Also,both superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in liver and kidney were examined.The pathological examination was observed.Results The Al levels in liver and kidney remarkably increased with increase of aluminum potassium sulfate intake (P<0.001),and the Cu,Zn,Mn levels decreased in different degrees (P<0.05,P<0.01).The SOD activities of liver and kidney significantly decreased in high dose group (P<0.05,P<0.01) .The GSH-Px activities of liver and kidney were inhibited in both low and high dose group.The liver and kidney damage was found among aluminum-loaded rabbits in pathological examination,and the extent relied on dosage.Conclusion Aluminum inhibited SOD and GSH-Px activities by decreasing Cu,Zn,Mn levels in liver and kidney of rabbits may constitute one of the factors for the mechanism of tissue injury by alnminum.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2002年第8期905-906,共2页
Chinese Journal of Public Health
基金
山东省卫生厅资助课题
关键词
硫酸铝钾
微量元素
抗氧化酶
肾毒性
肝毒性
实验研究
兔
aluminum potassium sulfate
trace elements
antioxidase
toxicity of kidney and liver
