摘要
目的：观察孟鲁司特联合酮替芬治疗儿童咳嗽变异性哮喘的疗效及安全性。方法：80例咳嗽变异性哮喘患儿随机分为观察组与对照组。两组患儿均予以特布他林5 mg雾化吸入,bid,急性期后停止使用,并予以酮替芬片0.5～1 mg,po bid,连用4周。观察组在此基础上加用孟鲁司特钠咀嚼片2.5～5 mg,qd,连用4周。观察两组患儿咳嗽缓解及消失时间、肺功能改善情况,评价两组疗效及安全性。结果：观察组患儿咳嗽缓解时间及消失时间均短于对照组（P〈0.05）。两组患儿治疗前肺功能比较,差异无统计学意义（P〉0.05）。治疗4周后,两组患儿肺功能均较治疗前改善（P〈0.05或0.01）,且观察组改善幅度明显优于对照组（P〈0.05或0.01）;观察组治疗总有效率明显优于对照组,两组患儿均未出现药品不良反应。结论：孟鲁司特联合酮替芬治疗儿童变异性哮喘能迅速的缓解患儿的咳嗽症状,改善肺功能,提高疗效,且安全性好。
Objective：To observe curative effect and security of montelukast combined with ketotifen on children with cough variant asthma. Methods：80 cases of children with cough variant asthma were divided into experimental group and control group at random. The children in two groups were given Terbutaline by spray inhalation 5mg per time twice a day, which shall be stopped after the acute stage, and were given ketotifen through the mouth 0.5-1 mg per time twice a day for 4 weeks. The children in experimental group were given montelukast dulcet 2.5-5mg per time once a day for 4 weeks. The clinical symptom relief and transference cure times, the lung function improvement condition of children in two groups were observed, and the treatment curative effect and security was evaluated as well. Results：Mter the medical treatment, clinical symptom relief and transference cure times of children in experimental group were both shorter than those in control group （ P 〈 0.05 ）. After comparing lung function of children in two groups before the medical treatment, no obvious staffs- tical difference appeared （ P 〉 0.05 ）. After 4 weeks＇ medical treatment, lung function of children in two groups was im- proved than before （P 〈 0.05 or P 〈 0.01 ）, and the improvement rate of children in experimental group was much higher than that in control group （P 〈 0.05 or P 〈 0.01 ）. Meanwhile, total efficiency of children in experimental group was much higher than that in control group. No adverse drug reactions appeared in children in two groups after the medical treatment. Conclusion：montelukast combined with ketotifen had reliable curative effect on relieving the clinical symptom, and impro- ving lung function with high security of children with cough variant asthma.
出处
《药物流行病学杂志》
CAS
2014年第9期533-535,共3页
Chinese Journal of Pharmacoepidemiology
