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BRAF^V600E基因突变和甲状腺乳头状癌临床病理特征关联性的Meta分析 被引量:7

Association of BRAFV600E mutation with clinical pathological features in papillary thyroid carcinoma:meta-analysis
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摘要 目的 探索甲状腺乳头状癌中BRAFV600E基因突变和病理特征的关联性.方法 检索Medline、PubMed、Web of Science等数据库收集相关文献,应用Meta分析计算比值比(odds ratio,OR)及95%可信区间(confident intervel,CI).结果 共有52篇相关文献纳入研究,12 029例甲状腺乳头状癌患者中BRAFV600E突变率为57.85%.结果显示:在甲状腺乳头状癌中,BRAFV600E基因突变和以下病理特征有关联性:病理分期(OR=1.89,95% CI为1.58~ 2.27)、淋巴结转移(OR=1.74,95% CI为1.42 ~2.14)、多灶性(OR=1.25,95% CI为1.07~ 1.46)、疾病复发(OR=2.26,95% CI为1.25~4.09).在亚洲人群中BRAFV600E基因突变和以下病理特征有关联性:病理分期(OR=1.56,95% CI为1.24 ~1.96)、淋巴结转移(OR=1.57,95%CI为1.25~ 1.99).在欧洲人群中BRAFV600E基因突变和以下病理特征有关联性:病理分期(OR=2.63,95% CI为2.10~3.30)、淋巴结转移(OR=1.97,95%CI为1.19~ 3.25)、多灶性(OR=1.35,95%CI为1.01~ 1.80).结论 病理分期、淋巴结转移、多灶性、疾病复发与BRAFV600E突变有关联性. Objective To evaluate the association between BRAF600E mutation and pathological features in papillary thyroid carcinoma (PTC).Methods The raleted studies were searched through Medline,PubMed,and Web of Science,and meta-analysis was used to calculate the OR and 95% CI of the study results.Results A total of 52 studies including 12 029 PTC patients was identified.The prevalence of BRAFV600EE mutation in PTC was 57.85%.There was a closed association between the BRAFV600E mutation and pathological features,including advanced TNM stage (OR =1.89,95% CI 1.58-2.27),lymph node metastasis (OR =1.74,95% CI 1.42-2.14),multifocality (OR =1.25,95% CI 1.07-1.46),and recurrence (OR =2.26,95% CI 1.25-4.09) of PTC.For Asians with PTC,the association between the BRAFV600E mutation and pathological features was indicated for advanced TNM stage(OR =1.56,95% CI 1.24-1.96) and lymph node metastasis(OR =1.57,95% CI 1.25-1.99).For Europeans with PTC,the association between the BRAFV600E mutation and pathological features was indicated for advanced TNM stage (OR =2.63,95% CI 2.10-3.30),lymph node metastasis(OR =1.97,95% CI 1.19-3.25),and multifocality (OR =1.35,95% CI 1.01-1.80).Conclusion There were associations between the BRAFV600EE mutation and advanced TNM stage,lymph node metastasis,multifocality,and recurrence of PTC.
出处 《中华耳鼻咽喉头颈外科杂志》 CAS CSCD 北大核心 2014年第9期759-764,共6页 Chinese Journal of Otorhinolaryngology Head and Neck Surgery
基金 吉林大学白求恩医学部医学科研支持计划青年科研基金(2013202013)
关键词 甲状腺肿瘤 乳头状 原癌基因蛋白质B—raf 突变 病理学 临床 META分析 Thyroid neoplasms Carcinoma, papillary Proto-oncogene protein B-raf Mutation Patholog clinical Meta-analysis
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