摘要
目的 探讨老年糖尿病患者认知功能障碍与胰岛素抵抗指数的相关性.方法 于2011年12月～2014年1月期间选取40例非糖尿病患者设为普通组,另分别选取40例老年糖尿病患者及40例老年糖尿病合并痴呆患者,设为糖尿病组及糖尿病合并组,对比三组患者糖化血红蛋白（HbA1c）、体重指数（BMI）、胰岛素抵抗指数（HOMA-IR）.结果 糖尿病合并痴呆组患者BMI、HbA1c、HOMA-IR分别为（26.13±1.45）kg/m2、（8.64±1.66）％、（0.71±0.08）,糖尿病组三项指标明显高于普通组,差异均有高度统计学意义（t=11.213,P=0.001;t=8.654,P=0.009;t=12.434,P=0.000）.糖尿病合并组BMI、HbA1c、HOMA-IR明显高于糖尿病组,差异均有统计学意义（t=6.464,P=0.021;t=5.226,P=0.028;t=7.287,P=0.011）;BMI、HbA1c、HOMA-IR三项指数均与MMSE评分呈负相关性.结论 老年糖尿病患者认知功能障碍与胰岛素抵抗指数显著相关,加强胰岛素抵抗指数的检测,能够较好地判断认知功能障碍.
Objective To explore cognitive dysfunction in elderly diabetic patients with insulin resistance index corre lation. Methods December 2011-2014 in January during the 40 cases classified as ordinary non-diabetic patients group, another 40 cases were selected elderly patients with diabetes and 40 cases of senile dementia combined with di- abetes, as diabetes group and diabetes combined group, compared three groups of patients glycosylated hemoglobin （HBAIC）, body mass index （BMI）, insulin resistance index （HbAlc）. Results Diabetic patients with dementia group BMI, HbA lc, HOMA-IR was （26.13± 1.45）kg/m2, （8.64± 1.66）%, （0.71 ±0.08）, three indicators of diabetes was signifi- cantly higher than normal comparison group differences were statistically significant significance （t=11.213, P=-0.001 ;t= 8.654, P=- 0.009;t=12.434, P=0.000）. Diabetes mellitus group BMI, HbAlc, HOMA-IR was significantly higher than the diabetic group, compared to the differences were statistically significant （t=6.464, P=0.021 ;t=5.226, P=0.028 ;t=7.287, P=-0.011）; BMI, HbAle, HOMA-IR index and three MMSE scores were negatively correlated. Conclusion Cognitive dysfunction in elderly patients with diabetes and insulin resistance index was significantly correlated to strengthen the detection of insulin resistance index, cognitive dysfunction can judge better.
出处
《中国现代医生》
2014年第28期138-140,共3页
China Modern Doctor
基金
浙江省医药卫生项目(2011KYB010)
关键词
老年糖尿病
认知功能障碍
胰岛素抵抗
Elderly diabetic
Cognitive dysfunction
Insulin resistance
