摘要
目的探讨冠心病(CHD)患者血清中同型半胱氨酸(HCY)、胱抑素C(CysC)、N-末端脑利钠肽前体(NT-proBNP)水平变化及临床意义。方法应用日立7100全自动生化分析仪及FIA8000免疫分析仪,分别检测52例冠心病患者和52名健康体检者血清中HCY、CysC及NT-proBNP的含量,并对结果进行统计学分析。结果冠心病患者血清中HCY、CysC及NT-proBNP含量均显著高于健康体检者,两者差异具有统计学意义(P<0.01);心肌梗死组与无心肌梗死组HCY、NT-proBNP水平两者比较差异具有统计学意义(P<0.05或P<0.01),CysC含量两者之间差异无统计学意义(P>0.05)。结论联合检测血清中HCY、CysC及NTproBNP水平,对临床诊断与治疗冠心病具有一定的指导意义。
Objective To investigate the changes of serum homocysteine （HCY）,cystatin C（CysC） and N-terminal probrain natriuretic peptide precursor （ NT-proBNP ） in patients with coronary heart disease and its clinical significance .Methods Hitachi 7100 automatic biochemical analyzer and FIA 8000 immunoassay analyzer were used to detect serum levels of HCY , CysC and NT-proBNP in 52 cases of coronary heart disease patients and 52 cases of healthy volunteers , and the results were statistically analyzed .Results Content of serum HCY and CysC and NT-proBNP in patients with coronary heart disease were significantly higher than those in healthy individuals （ all P〈0.01 ） .Between myocardial infarction group and no myocardial infarction group there were a statistically significant difference in level of Hcy and NT-proBNP（P〈0.05 or P〈0.01）,but there was no statistical significance in level of CysC（P〉0.05）.Conclusion Combined detection of serum HCY, CysC and NT-proBNP levels, has a ceitain guid-ing significance for clinical diagnosis and treatment of coronary heart disease .
出处
《中国临床新医学》
2014年第9期838-841,共4页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
