摘要
目的：观察大量盐酸氨溴索雾化吸入治疗呼吸机相关性肺炎过程中髓系细胞触发受体-1（sTREM-1）的变化。方法选择2010-03～2014-03收入黑龙江中医药大学附属第一医院重症医学科病房的66例呼吸机相关性肺炎患者，采用随机数字表法将患者分为治疗组32例与对照组34例，两组患者均按照临床症状给予西药规范治疗，治疗组在保持西药规范治疗的同时加用盐酸氨溴索雾化，每日4次，每次20 mL，两组患者疗程均为7 d。观察治疗前后患者的临床肺部感染评分和支气管肺泡灌洗液sTREM-1水平变化，并进行统计学分析。结果治疗后两组患者的临床肺部感染评分均有所改善（P＜0．05），治疗组患者临床症状明显优于对照组（P＜0.05）；治疗后两组患者sTREM-1水平均有所下降（ P＜0．05），治疗组下降较对照组显著（ P＜0.05）。结论在西医规范治疗基础上，大量盐酸氨溴索雾化能够降低临床肺部感染评分，提高治疗有效率，与其降低呼吸机相关性肺炎患者sTREM-1水平有关系。
Objective To observe the changes of myeloid cells start receptor -1 （sTREM-1） in the ventilator associated pneumonia patients with ambroxol hydrochloride atomization combined western medicine .Methods 64 patients with ventilator associated pneumonia admitted to intensive medicine ward of Heilongjiang University of Traditional Chinese Medicine from March 2010 to March 2014 , were randomly divided into treatment group （ 32 cases ） and control group （ 34 cases ） .The patients of two groups were given standard treatment , treatment group on the basis of western medicine treatment accepted ambroxol hydrochloride atomization , 4 times a day, every time 20 mL, and treatment time of two groups was 7 days.Results After the treatment, clinical pulmonary infection score improved in two groups （P〈0.05）, clinical symptom was better in the treatment group than in control group , the difference was statistically significant （P〈0.05）;sTREM -1 levels in two groups after treatment were decreased （ P 〈0.05 ）, the treatment group decreased more significantly than control group , the difference was statistically significant （ P 〈0 .05 ） .Conclusion On the basis of western medicine treatment, ambroxol hydrochloride （mu comfortable） atomization can reduce clinical pulmonary infection score, improve the treatment efficiency , which is related with the decrease of sTREM -1 level in the patients with ventilator associated pneumonia .
出处
《中国急救医学》
CAS
CSCD
北大核心
2014年第9期803-805,共3页
Chinese Journal of Critical Care Medicine
