摘要
目的观察抗骨质增生胶囊连续给药后对大鼠的毒性反应。方法抗骨质增生胶囊分别按照0.6 g/100 g、0.3 g/100 g、0.15 g/100 g的剂量连续给药13周,对照组灌胃等量的蒸馏水,停药4周,测量受试大鼠的体重,计算重要脏器质量系数,测定血液学及血液生化学指标,并作组织病理学检查。结果与对照组比较,各剂量组抗骨质增生胶囊对大鼠的体重增长、脏器系数、血液指标、血液生化学指标均无显著影响,病理学检查未见明显病变,停药后也未见延迟性毒性反应。结论抗骨质增生胶囊长期用药对大鼠无明显毒性,按临床拟用剂量服用是安全的。
Objective To observe the chronic toxicity and severity occurred after administration of Kangguzhizengsheng capsules in rats. Methods Wistar rats were randomly divided into 4 groups. Each group was given Kangguzhizengsheng capsule at dose of 0.6g/100 g, 0.3 g/100 g, 0.15 g/100 g daily for up to 13 weeks, respectively. Blank control group was given same bulk of distilled water. After the withdrawal of the drug for 4 weeks the rats＇ body weight, hematology, blood biochemistry analysis and organ coefficients were measured, and organ coefficient were measured and main organs were examined by pathological method. Results The outer appearance and behavior, body weights, organ coefficients, the indexes of hematology and biochemistry analysis in rats of drug taking groups showed no significant difference from those of control group. Pathological examination discovered no obvious pathological changes related to drug toxicity and no delayed toxicity reaction after drug withdrawal. Conclusion Kangguzhizengsheng capsules had no obvious toxicity in rats for long-term administration, and is safe to use with clinical dosage.
出处
《中国药物警戒》
2014年第9期516-520,共5页
Chinese Journal of Pharmacovigilance
关键词
抗骨质增生胶囊
大鼠
长期毒性
Kangguzhizengsheng capsules
rats
chronic toxicity
