摘要
喉癌是头颈部常见恶性肿瘤之一,以喉鳞状细胞癌为多。喉癌的发生和发展是一个多基因参与、多阶段、多层面的复杂过程。目前研究发现,喉癌与EGFR、COX-2、Survivin、VEGF、STAT3、p16、p53和Cyclin D1等基因相关。通过对这些基因的深入研究,基因治疗将为喉癌的临床治疗和预防提供新途径,对人类战胜喉癌有着极其重要的意义。
Laryngeal carcinoma is one of the most common malignant neoplasms of the head and neck The major pathological type of laryngeal cancers is squamous cell carcinoma. The occurrence and development of laryngeal cancer is more than one gene involved, multi-stage and multi-level complex process. Recent studies show that laryngeal carcinoma is related with EGFR, COX-2, Survivin, VEGF, STAT3, p16, p53 and Cyclin D1. Through in-depth study of these genes, gene therapy provides new ways for laryngeal cancer clinical treatment and prevention, and has an extremely important significance to overcome the human larynx.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2014年第9期1323-1330,共8页
Chinese Journal of Cell Biology
基金
浙江省自然科学基金(批准号:LY13H130001)
浙江省科技厅项目(批准号:2013C33208)
浙江省中医药管理局项目(批准号:2012ZAO85)资助的课题~~
关键词
喉癌
基因治疗
预防
laryngeal carcinoma
gene treatment
prevention
