摘要
目的观察妊娠期肝内胆汁淤积症患者应用熊去氧胆酸联合茵栀黄口服液治疗的效果和安全性。方法妊娠期肝内胆汁淤积症患者60例,依据治疗方法分为治疗组与对照组各30例,治疗组给予熊去氧胆酸250mg/次,4次/d,口服;茵栀黄口服液10mL/次,3次/d,口服;对照组仅给予熊去氧胆酸,用法、用量同治疗组。2组均连续治疗20d。比较2组治疗前、后瘙痒症状评分,血清总胆汁酸、总胆红素、直接胆红素、谷草转氨酶,谷丙转氨酶水平,记录妊娠结局。结果治疗组治疗后瘙痒症状评分、总胆汁酸、总胆红素、直接胆红素、谷丙转氨酶((0.57±0.68)分、(12.37±2.81)μmol/L、(13.74±2.84)μmol/L、(7.51±1.35)μmol/L、(68.78±12.85)u/L)较对照组((0.93±0.70)分、(14.60±4.79)μmol/L、(16.30±4.16)μmol/L、(9.91±2.39)μmol/L、(78.26±11.46)u/L)明显降低(P<0.05);谷草转氨酶水平及以上指标2组治疗后均较治疗前下降(P<0.05);治疗组新生儿出生体质量(2 845.00±341.93)g高于对照组(2 545.00±274.63)g(P<0.05),剖宫产率和早产率(83.33%、20.00%)与对照组(79.31%、24.14%)比较差异无统计学意义(P>0.05)。结论茵栀黄口服液联合熊去氧胆酸治疗肝内胆汁淤积症疗效优于单用熊去氧胆酸治疗。
Objective To evaluate the effect and the security of integrative ursodeoxycholic acid（UDCA）and Yinzhihuang oral liquid in the treatment of intrahepatic cholestasis of pregnancy（ICP）.Methods Sixty patients with ICP were divided into two groups according to the therapeutic methods,with 30 patients in each group.Observation group received UDCA orally 250 mg per time,four times a day,and Yinzhihuang oral liquid 10 mL per time,three times a day.Control group received only UDCA 250 mg per time,four times a day.Both two groups were treated for 20 days,and were compared the changes of itch score,and the serum levels of total bile acid,total bilirubin,direct bilirubin,glutamicoxal（o）acetic transaminase（GOT）and glutamic pyruvic transaminase（GPT）before and after treatment.The pregnancy outcomes were recorded.Results The itch score,the levels of total bile acid,total bilirubin,direct bilirubin and GOT were significantly lower in observation group（0.57±0.68,（12.37±2.81）μmol/L,（13.74±2.84）μmol/L,（7.51±1.35）μmol/L,（68.78±12.85）u/L）than those in control group（0.93±0.70,（14.60±4.79）μmol/L,（16.30±4.16）μmol/L,（9.91±2.39）μmol/L,（78.26±11.46）u/L）after treatment（P〈0.05）,and were significantly lower together with GPT after treatment in comparison with those before treatment in both groups（P〈0.05）.The birth body mass of newborns was higher in observation group（（2 845.00±341.93）g）than that in control group（（2 545.00±274.63）g）（P〈0.05）.There were no significant differences in the cesarean section rate（83.33%,20.00%）and preterm delivery rate（79.31%,24.14%）between two groups（P〉0.05）.Conclusion UDCA plus Yinzhihuang oral liquid is superior to UDCA for ICP.
出处
《中华实用诊断与治疗杂志》
2014年第10期1031-1032,共2页
Journal of Chinese Practical Diagnosis and Therapy
关键词
妊娠期肝内胆汁淤积症
熊去氧胆酸
茵栀黄口服液
Intrahepatic cholestasis of pregnancy
ursodesoxycholic acid
Yinzhihuang oral liquid
