摘要
溃疡性结肠炎(ulcerative colitis,UC)是一种自发性、慢性结肠黏膜炎症病变,其发病机制目前尚未清楚.大量的动物模型被应用于UC的研究,如葡聚糖硫酸钠(dextran sulphate sodium,DSS)诱导的小鼠结肠炎模型.DSS结肠炎模型是目前应用最为广泛的UC模型之一,其造模方法简便、价格便宜、成功率较高;且临床表现、病变部位、病理学表现与人类溃疡性结肠炎极其相似.基于DSS模型在对UC的研究中占有重要地位,本文将对DSS结肠炎模型特点、造模方法、机制及影响因素的研究进展进行综述.
Ulcerative colitis （UC） is an idiopathic, chronic inflammatory disorder of the colonic mucosa, and its etiology remains unclear. Animal models are commonly used to study UC, including the murine model of colitis induced with dextran sulfate sodium （DSS）. The murine model of DSS- induced colitis is well appreciated and widely used because of its simplicity, cheapness and high success rate. DSS-induced colitis has many similarities to human UC in location, clinical and histological features. In view of its indispensable position in the study of UC, we provide a brief overview of the animal model of DSS-induced colitis in terms of its features, modelling meth- ods, pathogenesis and influencing factors.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第22期3245-3250,共6页
World Chinese Journal of Digestology
基金
2014年广西研究生教育创新计划资助项目
No.YCSZ2014119~~
