摘要
目的探讨幽门螺杆菌(helicobacter pylori,HP)感染对老年人细胞免疫功能的影响。方法采用APAAP法检测44例幽门螺杆菌感染的老年患者(观察组)和同期30例正常老年人(对照组),比较T淋巴细胞亚群水平。结果观察组患者CD3、CD4细胞百分率、CD4/CD8比值显著低于对照组(P<0.05),而CD8细胞百分率水平显著高于对照组(P<0.05)。经HP根除治疗后CD3、CD4细胞百分率、CD4/CD8比值均有上升,与治疗前相比有显著差异(P<0.05),且与正常组类似。结论 HP感染的老年患者细胞免疫功能低下且紊乱,与消化性溃疡的发生有相关性。根除HP可以促进HP阳性老年患者免疫功能的恢复。
Objective To study the influence of helicobacter pylori on cellular immunity in old people.Methods Tlymphocyte subsets in peripheral blood of 44 old people with helicobacter pylori （HP） and T lymphocyte subsets were assayed.Results The percentages of CD3＋ and CD4 and the ratio of CD4/CD8cells in the patients were significantly lower（P〈0.05）,while the percentages of CD8 were higher than those in normal controls （P〈0.05）.The number of CD3,CD4and CD4/CD8 ratio were markedly increased after the anti-HP therapy.Conclusion Cellular immunity functions low and disorder in old people with HP,and this disorder is related with peptic ulcer.Anti-HP therapy can promoting recovery of immune function in old people with helicobacter pylori （HP）.
出处
《西部医学》
2014年第10期1316-1317,1322,共3页
Medical Journal of West China
关键词
老年
幽门螺杆菌
细胞免疫
Old people
Helicobacter pylori
Cellular immunity function
