摘要
目的研究中药组方＂莪黄汤＂保留灌肠对结、直肠癌组织E-Cadherin和VEGF的影响。方法选择我院2008年12月~2013年12月,Ⅱ~Ⅲ期手术治疗的结直肠癌患者62例,随机分为2组,中药组：＂莪黄汤＂保留灌肠6 d;对照组：温水保留灌肠6 d,术后肿瘤组织行免疫组织化学法检测,观察中药组与对照组肿瘤组织中E-Cadherin和VEGF的表达情况。结果中药组与对照组比较,肿瘤组织中E-Cadherin上调,但无统计学差异（P〉0.05）,VEGF表达下调,具有统计学差异（P〈0.05）。结论 ＂莪黄汤＂保留灌肠能下调结、直肠癌组织中VEGF的表达,并一定程度上影响E-Cadherin的表达,为莪黄汤组方进一步应用于临床抗肿瘤的研究,奠定了一定的基础。
Objective To study the prescription ＂E Huang Decoction＂effect on retention enema,E- Cadherin and VEGF in rectal cancer tissues. Methods Chose 62 cases of the colorectal cancer patients in our hospital from 2008 December- 2013 year in December,II ~ III stage operation treatment,they were randomly divided into 2 groups,Chinese medicine group： ＂E Huang Decoction＂enema 6d; control group： warm water retention enema 6d,detection of tumor tissue by immunohistochemistry after operation,the expression of E- Cadherin and the concept of VEGF to observe the traditional Chinese medicine group and the control group in tumor tissue. Results Chinese medicine group compared with the control group,the tumor tissue in the upregulation of E- Cadherin,but no significant difference（ P 〉 0. 05）,VEGF expression,with a significant difference（ P 〈 0. 05）. Conclusion＂I Decoction＂enema can lower the expression of VEGF node,in rectal cancer tissues,and to a certain extent,affect the expression of E- Cadherin,as I Decoction prescription further application in clinical anti- tumor,laid certain foundation.
出处
《现代中医药》
CAS
2014年第5期11-14,共4页
Modern Chinese Medicine
基金
陕西省教育厅自然科学专项课题(2010JK517)
关键词
结肠癌
直肠癌
莪黄汤
保留灌肠
E Huang Decoction
retention enema
E-Cadherin
VEGF
