期刊文献+

补肾强督方对强直性脊柱炎患者Dickkopf1蛋白水平的影响 被引量:14

Effects of Bushen Qiangdu Formula on the Level of Dickkopf1 in 45 Cases of Ankylosing Spondylitis
原文传递
导出
摘要 目的探讨补肾强督方治疗强直性脊柱炎(AS)的可能作用机制。方法本研究为前瞻性病例对照研究。应用酶联免疫吸附测定法(ELISA)检测45例AS患者(AS组,给予补肾强督方,每日1剂,疗程为6个月)治疗前后及40名健康人(健康组)血清Dickkopf1蛋白(DKK1)水平,并检测AS组治疗前后血沉(ESR)、C反应蛋白(CRP)、中医证候积分、巴氏强直性脊柱炎功能指数(BASFI)、巴氏强直性脊柱炎病情活动指数(BASDAI)、枕墙距、指地距、Schober试验、胸廓活动度水平。治疗过程中观察不良反应。结果 AS组治疗前血清DKK1水平较健康组明显降低(P<0.05),治疗后血清DKK1水平较治疗前明显升高(P<0.05),且与健康组比较差异无统计学意义(P>0.05)。治疗后ESR、CRP、中医证候积分、BASFI、BASDAI、枕墙距、指地距较治疗前均明显降低(P<0.05或P<0.01);Schober试验、胸廓活动度均较治疗前均明显升高(P<0.01)。患者治疗过程中未见明显不良反应。结论补肾强督方能明显改善AS患者临床症状、体征,且安全可靠,其可能作用机制与升高血清DKK1水平有关。 Objective To observe the effects of Bushen Qiangdu Formula( kidney-supplementing and Governor Vessel-strengthening formula) on the level of Dickkopf1( DKK1) in patients with ankylosing spondylitis( AS).Methods A prospective case-control study was conducted. Totally 45 cases of AS were selected as the AS group and given Bushen Qiangdu Formula one dose daily. The treatment lasted for 6 months. Forty healthy persons were selected as the healthy group. The level of DKK1 was detected with enzyme-linked immunosorbent assay( ELISA) in both groups. The levels of erythrocyte sedimentation rate( ESR),C-reactive protein( CRP),traditional Chinese medicine( TCM) syndrome scores,Bath Ankylosing Spondylitis Functional Index( BASFI),Bath Ankylosing Spondylitis Disease Activity Index( BASDAI),finger-floor distance,pulvinar-wall distance,Schober test and thorax activity were detected in the AS group. The adverse reactions were observed in the treatment. Results Before treatment,the level of DKK1 in the AS group was significantly lower than that in the healthy group( P〈0. 05). After treatment,the level of DKK1 was significantly increased in the AS group( P〈0. 05) and there was no significant difference between groups( P〈0. 05). The levels of ESR,CRP,TCM syndrome scores,BASFI,BASDAI,finger-floor distance and pulvinar-wall distance were significantly decreased after treatment( P〈0. 05 or P〈0. 01). The levels of Schober test and thorax activity were significantly increased after treatment( P〈0. 01). There was no adverse reaction occurring during the treatment. Conclusion The lower level of DKK1 in AS patients causes excessive activation of osteoblast pathway. Bushen Qiangdu Formula is effective and safe for AS. It can increase the level of DKK1 and interfere with new bone formation.
出处 《中医杂志》 CSCD 北大核心 2014年第20期1750-1753,共4页 Journal of Traditional Chinese Medicine
基金 中日友好医院科研基金资助项目(2010-QN-25)
关键词 强直性脊柱炎 补肾强督方 Dickkopf1蛋白 新骨形成 ankylosing spondylitis Bushen Qiangdu therapy Dickkopf1 new bone formation
  • 相关文献

参考文献15

  • 1Braun J,Bollow M,Remlinger G,et al.Prevalence of spondylarthropathies in HLA-B27 positive and negative blooddonors[J].Arthritis Rheum,1998,41(1):58-67.
  • 2Machado P,Landewe R,Braun J,et al.Both structural damage and inflammation of the spine contribute to impairment of spinal mobility in patients with ankylosing spondylitis[J].Ann Rheum Dis,2010,69(8):1465-1470.
  • 3Heiland GR,Appel H,Poddubnyy D,et al.High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis[J].Ann Rheum Dis,2012,71(4):572-574.
  • 4Uderhardt S,Diarra D,Katzenbeisser J,et al.Blockade of Dickkopf(DKK)-1 induces fusion of sacroiliac joints[J].Ann Rheum Dis,2010,69(3):592-597.
  • 5Schett G,Zwerina J,David JP.The role of Wnt proteins in arthritis[J].Nat Clin Pract,2008,4(9):473-480.
  • 6Luyten FP,Tylzanowski P,Lories RJ.Wnt signaling and osteoarthritis[J].Bone,2009,44(4):522-527.
  • 7孔维萍,阎小萍.补肾强督法治疗强直性脊柱炎292例临床观察[J].中国中医药科技,2008,15(4):290-290. 被引量:12
  • 8阎小萍,王昊,孔维萍.强直性脊柱炎与大(九娄)[J].中国医药学报,2002,17(10):612-614. 被引量:39
  • 9Van der Linden S,Valkenburg HA,Cats A.Evaluation of diagnostic criteria for ankylosing spondylitis:a proposal for modificalion of the New York criteria[J].Arthritis Rheum,1984,27(4):361-368.
  • 10Calin A,Garrett S,Whitelock H,et al.A new approach todefining functional ability in ankylosing spondylitis:the development of the Bath Ankylosing Spondylitis Functional Index[J].J Rheumatol,1994,21(12):2281-2285.

二级参考文献9

  • 1陶庆文,阎小萍,金笛儿,孔维萍,路平.强直性脊柱炎骨密度变化与中医辨证分型关系探讨[J].中国中西医结合杂志,2004,24(9):843-843. 被引量:23
  • 2孔维萍,阎小萍,秦林林,张卫,马海波,葛崇华,颜珏.强直性脊柱炎并骨质疏松97例临床观察[J].中医正骨,2005,17(11):3-6. 被引量:17
  • 3Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a proposal for modifica-lion of the New York criteria. Arthritis Rheum, 1984, 27 (4) : 361-368.
  • 4许志奇 郭素华 杨定焯.肾虚证骨矿含量的初步研究[J].中西医结合杂志,1991,11(3):222-222.
  • 5谢可永.补肾法治疗骨质疏松症55例疗效观察[J].中医杂志,1986,27(6):40-40.
  • 6Calin A, Garrett S,Whitelock H, et al. A new approach to defining functional ability in ankylosing spondylitis; the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol, 1994,21 : 2281.
  • 7Garrett S, Jenkinson TR, Kennedy LG, et al. A new approach todefining disease status in ankylosing spondylitis: the bath Asdisease activity index. J Rheumatol, 1994,21:2286.
  • 8Andersen JJ, Baron C, Van de, Het al. Ankylosing spondylitis assessment group preliminary definition of short term improvement in ankyiosing spondylitis. Arthritis Rheum, 2001,44: 1876.
  • 9阎小萍,王昊,孔维萍.强直性脊柱炎与大(九娄)[J].中国医药学报,2002,17(10):612-614. 被引量:39

共引文献59

同被引文献141

引证文献14

二级引证文献108

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部