摘要
目的 分析膀胱灌注化疗患者的生活质量与下尿路症状的相关性. 方法 选取2012年1月至2013年3月接受膀胱灌注化疗的膀胱癌患者46例,男31例,女15例.年龄35～71岁,平均54岁.采用生活质量问卷和下尿路症状问卷进行调查,调查时间分别为膀胱灌注化疗前及灌注后1、6个月.灌注前生活质量评分和下尿路症状评分分别为（55.7±6.2）分和（6.5±2.1）分.比较灌注后生活质量评分和下尿路症状评分的变化情况,分析下尿路症状评分和生活质量评分的相关性. 结果 本组46例患者灌注后1、6个月生活质量评分分别为（74.7±8.1）分和（78.5±10.6）分,下尿路症状评分分别为（8.9±2.0）分和（9.1±1.8）分,与灌注前比较差异均有有统计学意义（P＜0.05）.其中工作活动和自由支配时间维度受到的影响较大,分别由（8.3±2.1）分和（19.2±5.7）分升高至（14.3±5.6）分和（23.7±4.2）分.下尿路症状评分与自由支配时间维度呈正相关（r=0.61）.结论 膀胱灌注化疗会降低患者的生活质量,其中下尿路症状是影响生活质量的因素之一,提示改善下尿路症状可能有助于提高患者整体生活质量.
Objective To evaluate the quality of life （QoL） in patients undergone intravesical chemotherapy for non-muscle invasive bladder cancer and analyze the correlation of the quality of life and low urinary tract symptoms in this group of patients.Methods 31 male patients and 15 female patients were enrolled from Jan.2012 to Mar.2013.The average age was 54 （35-71） years.Questionnaires of QoL and core lower urinary tract symptom score （CLSS） were given to 46 patients before intravesical chemotherapy and the 1 st,6th month after starting the instillation.Before the instillation,the scores of QoL and CLSS were 55.7±6.2 and 6.5±2.1,respectively,the change of QoL and CLSS were compared to baseline,and then the correlation of the low urinary tract symptoms and quality of life was analyzed.Results At the end of 1st and 6th month,the QoL scores were 74.7±8.1 and 78.5± 10.6.The CLSS scores were 8.9±2.0 and 9.1 ± 1.8,respectively.The differences were significant （P 〈0.05） when compared to the baselines.The areas of working activity and free time were affected much more than other areas,and the scores increased from 8.3±2.1 and 19.2±5.7 to 14.3±5.6 and 23.7±4.2,respectively.The area of free time was found to be associated with local symptoms （r=0.61）.Conclusions Intravesical treatment can impair the QoL of patients.Low urinary tract symptom is an important factor and is associated with impairment of QoL,suggesting the relief of local symptoms may improve the overall quality of life.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2014年第9期664-667,共4页
Chinese Journal of Urology
基金
广西卫生厅资助课题（Z2010249）
关键词
生活质量
下尿路症状
膀胱灌注化疗
Quality of life
Lower urinary tract symptom
Intravesical chemotherapy
