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脓毒症的肝功能障碍发病机制及诊治研究 被引量：9

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摘要 脓毒症是临床常见危重症,虽然医疗技术不断发展,但严重脓毒症以及感染性休克依然是一个非常棘手的公共健康问题[1-2].肝脏参与炎症因子或炎症产物的清除,在代谢紊乱调节、内环境稳定以及机体的防御行为中起着非常重要的作用.肝功能障碍通常被认为只是休克和初期的低灌注所致,实际上,肝脏的损伤可能是多器官功能衰竭发生和进展一个非常主要的因素.然而,由于缺乏可靠的诊断工具使得我们尚不能检测到早期的肝功能障碍[3]。
作者 张剑 楼天正 张宁
机构地区 温州医科大学附属第六医院丽水市人民医院重症医学科
出处 《中华急诊医学杂志》 CAS CSCD 北大核心 2014年第10期1183-1185,共3页 Chinese Journal of Emergency Medicine
关键词 肝功能障碍 严重脓毒症 发病机制 多器官功能衰竭 感染性休克 诊治 炎症因子 医疗技术
分类号 R459.7 [医药卫生—急诊医学]
  • 相关文献

参考文献34

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  • 6赵伟,何新飙.脓毒症诱发急性肝功能障碍患者的危险因素和临床特征分析[J].中华急诊医学杂志,2012,21(1):61-64. 被引量：13
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二级参考文献11

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  • 10Blanco J,Muriel-Bombín A,Sagredo V,et al.Incidence,organ dysfunction and mortality in severe sepsis:a Spanish multicentre study[J].CritCare,2008,12 (6):R158.

共引文献26

同被引文献69

  • 1Dawei Wang,Yimei Yin,Yongming Yao.Advances in sepsis-associated liver dysfunction[J].Burns & Trauma,2014,2(3):97-105. 被引量：16
  • 2李晶铃,阴赪宏,王超,文艳,张淑文,王宝恩.内毒素血症时循环肾素-血管紧张素系统改变的实验研究[J].中国危重病急救医学,2006,18(2):92-95. 被引量：20
  • 3胡清华,杨兰,杨翠红.细胞因子和肝功能监测与脓毒血症预后的关系[J].武汉大学学报（医学版）,2006,27(5):657-659. 被引量：2
  • 4Roderburg C, Benz F, Vargas Cardenas D, et al. Elevated miR 122 serum levels are an independent marker of liver injury in inflammatory diseases. Liver Inl, 2015, 35: 1172-1184.
  • 5Petrowsky H, Rana A, Kaldas F M, et al. Liver transplanlation in highest acuity recipients: identifying factors to avoid futility. Ann Surg, 2014, 259: 1186-1194.
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引证文献9

二级引证文献75

中华急诊医学杂志
2014年 第10期

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