摘要
微小RNA（miRNA）是体内一类长度为21～25个核苷酸的内源性非编码单链RNA，其主要通过完全或不完全互补结合至靶基因的3’非编码区而调控靶基因的表达。miRNA有多种类型，其中miR-128在多种疾病和正常组织中均不同程度的表达，具有广泛的调节作用。研究发现miR-128参与了神经胶质瘤、白血病、胃癌、肺癌及乳腺癌的发生过程，对细胞的分化、增殖、迁移和凋亡有重要作用。本文就miR-128在肿瘤中的研究进行详细阐述，以期为肿瘤的治疗提供新的靶点。
MicroRNA （miRNA） is a kind of small endogenous non-coding single RNA containing 21-25 nucleotides, which regulates the expression of target genes through complementary binding to the 3＇ untranslated region completely or incompletely. MiR-128, one of the subtypes of miRNA, expresses differently in a variety of diseases and normal tissues and plays an enormous role. Studies found that miR-128 played fundamental roles in various aspects of cellular function including differentiation, proliferation, migration and apoptosis in the development of several kinds of tumors including glioma, leukemia, stomach cancer, lung cancer and breast cancer. In this review, we will articulate the relationship between miR-128 and cancers, hoping to provide a new target for the treatment of tumor.
出处
《临床肿瘤学杂志》
CAS
2014年第9期849-853,共5页
Chinese Clinical Oncology
基金
国家自然科学基金资助项目(81270420)
湖南省高校创新平台开放基金资助项目(10K051)
湖南省自然科学基金省市联合(衡阳)基金重点项目(12JJ8013)
