摘要
目的:探讨Th1、Th2、Th17代表性细胞因子IFN-γ、IL-4、IL-17在口腔扁平苔藓(OLP)发病中的作用及意义。方法:采用ELISA法测定60例OLP患者(糜烂型30例,非糜烂型30例)及25例健康人血清中IFN-γ、IL-4、IL-17表达水平,并分析其与OLP临床特征相关性。结果:IFN-γ表达水平在非糜烂型及糜烂型OLP组均低于对照组(P<0.01);IL-4表达水平在非糜烂型及糜烂型OLP组均高于对照组(P<0.01);IFN-γ/IL-4比值水平在非糜烂型和糜烂型OLP组均低于正常对照组(P<0.01)。IL-17表达水平在糜烂型OLP组高于对照组(P<0.05);非糜烂型OLP组与对照组差异无统计学意义(P>0.05)。结论:IFN-γ表达降低和IL-4表达增高导致IFN-γ/IL-4比值降低是OLP的免疫病因学因素之一,IL-17蛋白表达增高主要与糜烂型OLP炎症过程有关。
Objective：To study the expression of IFN-γ,IL-4 and IL-17 in peripheral blood of patients with oral lichen planus（OLP）. Methods：The level of IFN-γ,IL-4 and IL-17 in peripheral blood were detected by ELISA in 60 OLP patients（including 30 erosive ca-ses and 30 non-erosive cases）and 25 healthy volunteers（controls）.Data were statistically analyzed by SPSS 13.0.Results：（1 ）The level of IFN-γin serum of patients with non-erosive OLP and erosive OLP were significantly lower than that in the controls（P〈0.01）;while the level of IL-4 in the patients were significantly higher than that in the controls（P〈0.01）,and the IFN-γ/IL-4 ratio in non-ero-sive OLP and erosive groups were significantly lower than that in the control group（P〈0.01）;（2）The level of IL-17 in erosive OLP pa-tients was significantly higher than that in the controls（P〈0.05）,while no statistical difference was seen between non-erosive OLP group and the control group（P〉0.05）.Conclusion：The down-regulated level of IFN-γand up-regulated level of IL-4,which result in the decrease of IFN-γ/IL-4 ratio,might be one of the immune etiological factors of OLP,while the up-regulated level of IL-17 protein in OLP may be mainly related with the inflammatory processes of OLP.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2014年第5期698-700,共3页
Journal of Practical Stomatology
基金
贵州省优秀科技教育人才省长专项资金项目(编号:省专合字2009-38)
