摘要
[目的]研究肿瘤坏死因子-α（TNF-α）在溃疡性结肠炎（UC）患者血清中的表达水平及临床意义,并探讨UC患者血清中TNF-α水平与中医证型（大肠湿热证和脾虚湿盛证）的相关性.[方法]收集2011年5月-2013年12月我院和广州市中医医院消化科门诊及病房符合诊断标准的UC患者100例.将100例患者按Mayo UCAI标准分为活动期和缓减期,再将活动期的患者分为轻度活动、中度活动和重度活动,并进行中医辨证分型,检测血清TNF-α水平.[结果]UC活动期患者血清中TNF-α水平与缓解期组比较明显增高,差异有统计学意义（P＜0.05）.UC缓解期患者血清中TNF-α水平与活动期轻度比较,差异无统计学意义,与活动期中、重度比较,差异有统计学意义（P＜0.05）.UC患者不同病情程度血清中TNF-α水平比较,重度组UC患者血清TNF-α水平明显高于轻、中度组患者,而中度组患者又高于轻度组患者,三者比较差异有统计学意义（P＜0.05）.中医辨证分型大肠湿热证UC患者血清中TNF-α水平明显高于脾虚湿盛证患者,二者比较差异有统计学意义（P＜0.05）.[结论]各组血清中TNF-α含量增高与UC严重程度相平行,说明TNF-α对于判断UC患者组织炎症损伤的程度,观察病情发展及变化,有一定的诊断价值.UC患者血清中TNF-α水平与辨证分型有关,测量血清中TNF-α水平,可以协助中医辨证分型,从而为临床上UC的中医辨证提供参考依据,提高本病的临床诊治水平.
[Objective]To study the expression and Clinical Significance of TNF-a in the serum of patients with ulcerative colitis（UC）. To explore the relationship between the serum levels of TNF-a and the chinese medicine syndrome（damp-heat syndrome, spleen deficiency and dampnees syndrome）. [-Methods] From May 2011 to December 2013,100 UC out-or inpatients at the Department of Digestive Diseases of Guangzhou and Yangchun Municipal Hospital of Traditional Chinese Medicine were collected, who were divided into the active period and the remission period group by the Mayo UCAI standards, and then the active period patients were divided into the mild activity, moderate activity and severe activity, at the same time, syndrome differentiation typing, detecting the serum levels of TNF-a. Results]The active period oup was significantly higher then the remission period group in patients with the serum levels of TNF-a, e difference was statistically significant（P〈0.05）. The remission period in patients with the serum levels TNF-a compared with the mild activity, the difference was not statistically significant, compared with e moderate activity and severe activity, the difference was statistically significant（P〈0.05）. Patientswith UC of different disease extent in the serum levels than the mild group of patients, the moderate group was of TNF-a, the severe group significantly higher higher than the mild group of patients, the difference was statistically significant between the three groups （P〈0.05）. The damp-heat syndrome in patients with UC the serum levels of TNF-a were significantly higher than the Spleen deficiency and dampness syndrome, the difference was statistically signifieant（P〈0.05）. EConelusionThe serum levels of TNF-a increased in parallel with the severity of UC, the TNF-a to determine the extent of the UC tissue inflammation injury, observe the progression of the disease and changes has some diagnostic values. The serum levels of TNF-a of UC patients with the the Chinese medicine syndrome related, detecting the serum levels of TNF-a can help syndrome differentiation typing, improving the level of diagnosis and treatment, improving clinical efficacy.
出处
《中国中西医结合消化杂志》
CAS
2014年第9期525-528,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
TNF-Α
溃疡性结肠炎
中医证型
TNF-a
ulcerative colitis
the Chinese medicine syndrome
