摘要
目的探讨瑞舒伐他汀对老年人群颈动脉粥样硬化的影响。方法选取76例颈动脉粥样硬化患者,根据随机数字表法随机分成瑞舒伐他汀10mg组和瑞舒伐他汀20mg组,均综合干预高血压、高血脂等症,比较两组治疗前、治疗后1个月、3个月、6个月血脂、同型半胱氨酸和颈动脉内膜厚度的变化。结果两组血清TC、LDL-C、TG治疗后1个月开始明显下降,3、6个月均下降明显(P<0.05,0.01),Hcy瑞舒伐他汀10mg组6个月开始明显降低(P<0.05),瑞舒伐他汀20mg组3个月开始明显降低(P<0.05),两组颈动脉IMT 6个月开始明显降低(P<0.05),瑞舒伐他汀20mg组对Hcy及IMT作用明显优于10mg组(P<0.05),差异均有统计学意义。结论瑞舒伐他汀具有良好的调脂、抗颈动脉粥样硬化作用,治疗6个月后可明显降低颈动脉内膜厚度。
Objective To explore the effect of Rosuvastatin on homocysteine and carotid intimamedia thickness in elderly patients with carotid atherosclerosis.Methods A total of 76 patients with carotid atherosclerotic were randomly divided into Rosuvastatin with 10 mg group and Rosuvastatin with 20 mg group,were comprehensive intervened for hypertension and high blood fat disease.TC,TG,HDL-C,Homocysteine and carotid IMT were detected before the treatment and on the 1th,3th,6th months after treatment respectively.Results After treatment,the serum levels of TC,TG,LDL-C decreased after 1month of medication than those before（P〈0.05）,the levels of Homocysteine decreased in Rosuvastatin with 10 mg group after 6months,and it decreased in Rosuvastatin with 20 mg group after 3months（P〈0.05）,the carotid IMT all decreased after 6months（P〈0.05）,the effect of Hcy and carotid IMT in Rosuvastatin with 20 mg group was obviously better than it with 10 mg group after 6months.Conclusion Rosuvastatin could effectively decrease the serum lipids,it has the role of anti-carotid atherosclerosis.Carotid IMT could be decreased after 6months of rosuvastatin medication in elderly patients with carotid atherosclerosis.
出处
《青岛医药卫生》
2014年第5期325-327,共3页
Qingdao Medical Journal
