摘要
目的 探讨儿童血清25羟-维生素D3[25-（OH）D3]水平与体质量、肥胖程度、体质量指数（BMI）、血脂的关系,以及他们在肥胖儿童中可能的发生机制.方法 以2011年7月至2013年2月在无锡市妇幼保健院儿童营养门诊就诊的儿童为研究对象,共244例.调查所有受试者每日服用维生素D情况,测量身高、体质量、BMI及25-（OH）D3水平和微量元素,其中38例3岁以上肥胖儿童测定脂代谢水平.结果 1.肥胖儿童的血清25-（OH）D3水平为（68.31 ±23.06） nmol/L,其中36个月龄以上组肥胖儿童最低,为（55.03±15.18） nmol/L.2.肥胖组和超重组儿童血清25-（OH） D3水平远低于正常体质量组儿童水平（F=4.739,P＜0.05）.3.重度肥胖儿童25-（OH） D3水平显著低于轻、中度肥胖儿童（F=9.711,P＜0.05）.4.儿童体质量、身高/体质量百分比及BMI与25-（OH） D3水平呈负相关（r=-0.365、-0.237、-0.175,P均＜0.001）.5.3岁以上肥胖儿童体质量、三酰甘油水平与25-（OH） D3均呈负相关（r=-0.476、-0.324,P均＜0.05）.结论 血清25-（OH）D3水平降低与肥胖有关.其原因可能是肥胖者脂肪组织增多,维生素D滞留在脂肪细胞中,导致血清维生素D水平减低.肥胖儿童体内维生素D的消耗高于正常儿童,需要补充更多的维生素D才能达到正常25-（OH）D3水平.
Objective To examine the relationship between the concentration of 25-hydroxy vitamin D3 [25-（OH） D3] in the serum and the body mass,the severity of obesity,body mass index（BMI）,blood lipid,and their predicting role in obesity children.Methods The study recruited 244 subjects,who see the doctor in Wuxi Maternal and Child Health Hospital,Childhood Nutrition Outpatient from Jul.2011 to Feb.2013.The intake dose of vitamin D each day was investigated,and weight,height,BMI,concentration of 25-（OH） D3 in serum,and microelement were also measured.In addition,lipid metabolism of 38 cases with obesity over 3 years old was determined.Results 1.The serum 25-（OH） D3 concentration of obese children was （68.31 ± 23.06） nmol/L.The concentration of 25-（OH） D3 was lowest in the group of obese children over 36 months of age[（55.03 ± 15.18） nmol/L].2.The concentration of 25-（OH） D3 in the group of obese and overweight children was far lower than that of the children in the normal group （F =4.739,P 〈0.05）.3.The concentrations of 25-（OH） D3 in the severely obese children was significantly lower than that of the mild and moderate obesity children（F =9.711,P 〈 0.05）.4.There were significantly inverse associations of serum 25-（OH） D3 with weight,weight and height percentage,BMI （r =-0.365,-0.237,-0.175,all P 〈 0.001）.5.There were significantly inverse associations between the concentration of 25-（OH） D3 in serum with weight,triglyceride in obese children more than 3 years old （r =0.476,-0.324,all P 〈 0.05）.Conclusions The decreasing level of 25-hydroxy vitamin D3 in the serum was associated with obesity.The cause of it might be the increase of the obese adipose tissue,vitamin D getting trapped in fat cells,and all these factors can lead to a less serum vitamin D levels.The vitamin D consumption of obese children is higher than that of normal children,and should supply more vitamin D to reach normal 25-（OH） D3 level.
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2014年第19期1476-1478,共3页
Chinese Journal of Applied Clinical Pediatrics
