摘要
目的研究黎药荔花鼻窦炎处方的化学成分。方法采用多种色谱手段分离化合物,运用理化性质和波谱技术鉴定化合物的结构;考察化合物1对脂多糖(LPS)诱导的巨噬细胞RAW264.7释放NO的影响。结果从荔花鼻窦炎处方中分离得到2个化合物,分别鉴定为尖瓣海莲苷A-4-甲醚(1)、尖瓣海莲苷C(2)。化合物1在50μmol/L时对LPS诱导的RAW264.7细胞释放NO有轻微的抑制作用。结论化合物1为1个新的酚苷类化合物,化合物2为首次从荔花鼻窦炎处方中分离得到,尖瓣海莲苷A-4-甲醚具有一定的抗炎作用。
Objective To study the chemical constituents of Li medicine Lihua Bidou Yan prescription. Methods Chemical constituents were isolated by using various column chromatography. The structures were elucidated on the basis of physicochemical constants and spectral analysis. The anti-inflammatory activities of compound 1 were evaluated using LPS-induced RAW 264.7 cells. Results Two compounds were obtained from Lihua bidou yan Prescription and identified as rhyncoside A-4-methly ether（1） and rhyncoside C（2）, respectively. The NO production in LPS-induced RAW264.7 cells was slightly inhibited by compound 1 at a concentration of 50 μmol/L. Conclusion Compound 1 is a new phenolic glycoside; Compound 2 is obtained from the prescription for the first time. Rhyncoside A-4-methyl ether has anti-inflammatory activity.
出处
《中草药》
CAS
CSCD
北大核心
2014年第17期2437-2439,共3页
Chinese Traditional and Herbal Drugs
基金
海口市重点科技计划项目(0000252)
关键词
黎药
荔花鼻窦炎处方
薜荔
角花胡颓子
酚苷类
尖瓣海莲苷A-4-甲醚
尖瓣海莲苷C
抗炎
Li medicine
Lihua Bidou Yan Prescription
Ficus pumila L.
Elaeagnus gonyanthes Benth.
phenolic glycoside
rhyncoside A-4-methly ether
rhyncoside C
anti-inflammation
