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阿奇霉素-聚环糊精超分子包合物的制备及表征 被引量：1

Preparation and characterization of inclusion complex of Azithromycin with β-cyclodextrin polymer
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摘要 以β-环糊精聚合物(β-cyclodextrin polymer,β-CDP)为主体分子、阿奇霉素(Az)为客体分子,制备了阿奇霉素-聚环糊精超分子包合物(Az-CDP),并通过红外光谱、核磁共振氢谱、X-射线粉末衍射、热重分析、紫外可见吸收光谱等方法进行表征.结果表明,Az-CDP超分子包合物比Az具有更高的水溶性和热稳定性,在生物医药领域将具有良好的应用前景. A new water-soluble inclusion complex of Azithromycin （Az） with β-cyclodextrin polymer （β-CDP） is prepared by a facile strategy and characterized by Fourier transform infrared spec- trometer, 1H NMR spectroscopy, powder X-ray diffractometry, and thermograrimetric analysis. The solubility and thermostability of Azithromycin-cyclodextrin polymer （Az-CDP） are greatly en- hanced due to the water-soluble CDP host. Possibly, the new type of Az-CDP inclusion complex will have a good application prospect in the field of biomedicine.
作者 施翔 张旺 龚向东 刁国旺
机构地区 扬州大学化学化工学院 泰州职业技术学院
出处 《扬州大学学报（自然科学版）》 CAS 北大核心 2014年第3期29-31,40,共4页 Journal of Yangzhou University：Natural Science Edition
基金 国家自然科学基金资助项目(21273195) 泰州市科技支撑计划资助项目(工业部分)(TG201241)
关键词 阿奇霉素 Β-环糊精聚合物 超分子化学 水溶性 Azithromycin β-cyclodextrin polymer supermolecular chemistry water solubility
分类号 O636.1 [理学—高分子化学]
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参考文献10

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二级参考文献21

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扬州大学学报（自然科学版）
2014年 第3期

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